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Dominic J. Withers
Researcher at Imperial College London
Publications - 117
Citations - 17823
Dominic J. Withers is an academic researcher from Imperial College London. The author has contributed to research in topics: Insulin & Insulin receptor. The author has an hindex of 53, co-authored 108 publications receiving 16410 citations. Previous affiliations of Dominic J. Withers include Howard Hughes Medical Institute & Hammersmith Hospital.
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Journal ArticleDOI
Disruption of IRS-2 causes type 2 diabetes in mice
Dominic J. Withers,Julio Sanchez Gutierrez,Heather H. Towery,Deborah J. Burks,Jian-Ming Ren,Stephen F. Previs,Yitao Zhang,Dolores Bernal,Sebastian Pons,Gerald I. Shulman,Susan Bonner-Weir,Morris F. White +11 more
TL;DR: It is shown that disruption of IRS-2 impairs both peripheral insulin signalling and pancreatic β-cell function, indicating that dysfunction of IRS-2 may contribute to the pathophysiology of human type 2 diabetes.
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Inhibition of food intake in obese subjects by peptide YY3-36.
Rachel L. Batterham,Mark Cohen,Sandra M. Ellis,Carel W. le Roux,Dominic J. Withers,Gary Frost,Mohammad A. Ghatei,Stephen R. Bloom +7 more
TL;DR: It is found that obese subjects were not resistant to the anorectic effects of PYY, and endogenous PYY levels were low in obese subjects, suggesting that PYY deficiency may contribute to the pathogenesis of obesity.
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Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Colin Selman,Jennifer M. A. Tullet,Daniela Wieser,Elaine E. Irvine,Steven J. Lingard,Agharul I. Choudhury,Marc Claret,Hind Al-Qassab,Danielle Carmignac,Faruk Ramadani,Angela Woods,Iain C. A. F. Robinson,Eugene Schuster,Rachel L. Batterham,Sara C. Kozma,George Thomas,David Carling,Klaus Okkenhaug,Janet M. Thornton,Linda Partridge,David Gems,Dominic J. Withers,Dominic J. Withers +22 more
TL;DR: It is shown in mice that deletion of ribosomal S6 protein kinase 1 (S6K1), a component of the nutrient-responsive mTOR (mammalian target of rapamycin) signaling pathway, led to increased life span and resistance to age-related pathologies, such as bone, immune, and motor dysfunction and loss of insulin sensitivity.
Journal ArticleDOI
Phosphoinositide 3-kinase : the key switch mechanism in insulin signalling
TL;DR: Using mechanisms such as this, PI 3-kinase is able to act as a molecular switch to regulate the activity of serine/threonine-specific kinase cascades important in mediating insulin's effects on endpoint responses.
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Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
TL;DR: The findings demonstrate that mTOR is a direct target for PKB and support the conclusion that regulation of phosphorylation of Ser(2448) is a point of convergence for the counteracting regulatory effects of growth factors and amino acid levels.