Dominique Ferrandon

TL;DR: The striking parallels between the adult fly response and mammalian innate immune defences described below point to a common ancestry and validate the relevance of the fly defence as a paradigm for innate immunity.

TL;DR: A mutation in a gene coding for a putative transmembrane protein, PGRP-LC, which reduces survival to Gram-negative sepsis but has no effect on the response to gram-positive bacteria or natural fungal infections is reported.

TL;DR: Using GFP reporter transgenes, it is shown that all seven Drosophila antimicrobial peptides can be induced in surface epithelia in a tissue-specific manner and drosomycin expression, which is regulated by the Toll pathway during the systemic response, isregulated by imd in the respiratory tract, thus demonstrating the existence of distinct regulatory mechanisms for local and systemic induction of antimacterial peptide genes in Droseophila.

TL;DR: It is shown that staufen protein colocalizes with bcd mRNA at the anterior, and that this localization depends upon its association with the mRNA.

TL;DR: It is shown that imd functions upstream of the DmIKK signalosome and the caspase DREDD in the control of antibacterial peptide genes and is involved in the apoptotic response to UV irradiation, raising the possibility that antibacterial response and apoptosis share common control elements in Drosophila.