Showing papers in "Developmental Cell in 2001"

TL;DR: In healthy cells, fusion and fission events participate in regulating mitochondrial morphology and inhibition of Drp1 blocks cell death, implicating mitochondrial fission as an important step in apoptosis.

TL;DR: Analysis of a transgenic mouse line in which beta-galactosidase activity is observed in the embryonic right ventricle and outflow tract of the heart and in contiguous splanchnic and pharyngeal mesoderm suggests that arterial pole myocardium originates outside the classical heart field.

TL;DR: It is proposed that modulation of cytoplasmic beta-catenin levels, associated with FGF-induced downregulation of E-cadherin, provides a molecular link between FGF and Wnt signaling pathways at the streak.

TL;DR: It is suggested that interference in O-mannosyl glycosylation is a new pathomechanism for muscular dystrophy as well as neuronal migration disorder.

TL;DR: The data provide direct genetic evidence for the requirement of secreted Wnt antagonists during embryonic patterning and implicate Dkk1 as an essential inducer during anterior specification as well as a regulator during distal limb patterning.

TL;DR: Findings indicate that both isp-1 and daf-2 mutations increase life span by lowering oxidative stress and result in the maximum life span increase that can be produced in this way.

TL;DR: It is suggested that methylation of a cell type-specific gene promoter is a pivotal event in regulating lineage specification in the developing brain.

TL;DR: L-Sox5 and Sox6 are highly identical Sry-related transcription factors coexpressed in cartilage, thereby essential for endochondral skeleton formation and redundant, potent enhancers of chondroblast functions.

TL;DR: In this paper, sequence analysis revealed phospholipase A2 motifs in the capsid proteins of parvoviruses and showed that PLA2 activity is critical for efficient transfer of the viral genome from late endosomes/lysosomes to the nucleus to initiate replication.

TL;DR: The mitotic checkpoint blocks the activation of the anaphase-promoting complex (APC) until all sister chromatids have achieved bipolar attachment to the spindle, and the ability of BubR1 to inhibit APC may be regulated by kinetochore tension or occupancy.

TL;DR: Experimental and genetic evidence is provided that glypican Knypek acts during vertebrate gastrulation as a positive modulator of noncanonical Wnt signaling to establish polarized cell behaviors underlying convergent extension movements.

TL;DR: It is shown that imd functions upstream of the DmIKK signalosome and the caspase DREDD in the control of antibacterial peptide genes and is involved in the apoptotic response to UV irradiation, raising the possibility that antibacterial response and apoptosis share common control elements in Drosophila.

TL;DR: The signaling pathways that have been adopted by the mammary gland for its own purposes, and the functions they perform are discussed.

TL;DR: It is shown that daf-9 acts downstream of these inputs but upstream of dAF-12, indicating that lipophilic hormones influence nematode metabolism, diapause, and life span.

TL;DR: It is demonstrated that the zebrafish wnt8 locus is required during gastrulation to pattern both the mesoderm and the neural ectoderm properly, and that either coding region of the bicistronic RNA can rescue the deficiency phenotype.

TL;DR: Insight is provided into the normal cellular function of merlin and how Nf2 mutation contributes to tumor initiation and progression by placing merlin in a signaling pathway downstream of the small GTPase Rac.

TL;DR: Genetic and biochemical evidence indicates that Neur is a RING-type, E3 ubiquitin ligase that positively regulates the N pathway by promoting the endocytosis and degradation of Dl.

TL;DR: A critical role for mRNA metabolism in the control of ABA signaling as well as in the regulation of A BA homeostasis is suggested.

TL;DR: EA-15 can redirect the biological outcome of MAP kinase signaling by regulating the subcellular localization of ERK MAP kinases in the cytoplasm.

TL;DR: RIN1 contains a region homologous to the catalytic domain of Vps9p-like Rab guanine nucleotide exchange factors (GEFs), which is necessary and sufficient for RIN1 interaction with the GDP-bound Rabs, Vps21p, and Rab5A.

TL;DR: The molecular mechanisms of developmental timing in C. elegans and Drosophila are surveyed and how common regulatory pathways are beginning to emerge are outlined.

TL;DR: A role for Scc1 in mitotic regulation, along with cohesion is suggested, although temporal differences exist between eukaryotes in cohesin loss from chromosome arms, as distinct from centromeres.

TL;DR: It is demonstrated that Bim levels set the threshold for initiation of apoptosis in several tissues and suggest that degenerative diseases might be alleviated by blocking BH3-only proteins.

TL;DR: Recent studies have yielded a number of important insights into the mechanisms of hair follicle development and cycling and have highlighted the particularly important roles played by stem cells and Wnt signaling pathways.

TL;DR: It is found that Dl endocytosis and N signaling are greatly stimulated by expression of neuralized (neur) and the potent modulatory effect of Neur on Dl activity makes Neur a candidate for establishing signaling asymmetries within cellular equivalence groups.

TL;DR: This study shows that the germ cell nuclear factor (GCNF), an orphan nuclear receptor, represses Oct4 gene activity by specifically binding within the proximal promoter, and establishes a link to transcriptional corepressors mediating repression by GCNF.

TL;DR: The nodal family of TGFbeta-related ligands have emerged as critical regulators of early vertebrate embryogenesis and their intracellular transducers allow a comparison of how this signaling pathway is used in the patterning of early embryos of these different vertebrates.

TL;DR: The characteristics and properties of these cell populations, the relationship between them, and the potential for stem cell-based muscle therapeutics are discussed.

TL;DR: Several of the proteins involved in vesicle targeting to the yeast Golgi apparatus show distant homology to components of two other putative tethering complexes, the exocyst and the Vps52/53/54 complex, revealing that tethering factors involved in different membrane traffic steps are structurally related.

TL;DR: This work identifies a tissue polarity gene, diego, that comprises six ankyrin repeats and colocalizes with Flamingo at proximal/distal boundaries and suggests that Frizzled acts through Diego to promote local clustering of Flamedo, and that clustering in one cell nonautonomously propagates to others.