J
Jean-Marc Reichhart
Researcher at University of Strasbourg
Publications - 105
Citations - 19469
Jean-Marc Reichhart is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Drosophila Protein & Innate immune system. The author has an hindex of 60, co-authored 105 publications receiving 18345 citations. Previous affiliations of Jean-Marc Reichhart include University of Kentucky & Centre national de la recherche scientifique.
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Journal ArticleDOI
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
TL;DR: It is shown that mutations in the Toll signaling pathway dramatically reduce survival after fungal infection and the intracellular components of the dorsoventral signaling pathway and the extracellular Toll ligand, spätzle, control expression of the antifungal peptide gene drosomycin in adults.
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Drosophila innate immunity: an evolutionary perspective.
TL;DR: Recent evidence indicates that recognition of infectious nonself agents results from interactions between microbial wall components and extracellular pattern recognition proteins, and evolutionary perspectives on the antimicrobial defenses of Drosophila are discussed.
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Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms
TL;DR: It is demonstrated that Drosophila that are naturally infected by entomopathogenic fungi exhibit an adapted response by producing only peptides with antifungal activities, mediated through the selective activation of the Toll pathway.
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Immunity-Related Genes and Gene Families in Anopheles gambiae
George K. Christophides,Evgeny M. Zdobnov,Carolina Barillas-Mury,Ewan Birney,Stéphanie Blandin,Claudia Blass,Paul T. Brey,Frank H. Collins,Alberto Danielli,George Dimopoulos,Charles Hetru,Ngo Thi Hoa,Jules A. Hoffmann,Stefan M. Kanzok,Ivica Letunic,Elena A. Levashina,Thanasis G. Loukeris,Gareth J Lycett,Stephan Meister,Kristin Michel,Luis F. Moita,Hans-Michael Müller,Mike A. Osta,Susan M. Paskewitz,Jean-Marc Reichhart,Andrey Rzhetsky,Laurent Troxler,Kenneth D. Vernick,Dina Vlachou,Jennifer Volz,Christian von Mering,Jiannong Xu,Liangbiao Zheng,Peer Bork,Fotis C. Kafatos +34 more
TL;DR: 242 Anopheles gambiae genes from 18 gene families implicated in innate immunity are identified and marked diversification relative to Drosophila melanogaster is detected, confirming that sequence diversification is accompanied by specific responses to different immune challenges.
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Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
TL;DR: The mutation semmelweis (seml) inactivates the gene encoding a peptidoglycan recognition protein (PGRP-SA), indicating the existence of a distinct recognition system for fungi to activate the Toll pathway.