D
Donald B. DeFranco
Researcher at University of Pittsburgh
Publications - 151
Citations - 9233
Donald B. DeFranco is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Glucocorticoid receptor & Receptor. The author has an hindex of 53, co-authored 147 publications receiving 8742 citations. Previous affiliations of Donald B. DeFranco include Boston Children's Hospital & University of California, San Francisco.
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Journal ArticleDOI
Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region.
Farhang Payvar,Donald B. DeFranco,Gary L. Firestone,Bruce A. Edgar,Örjan Wrange,Sam Okret,Jan-Åke Gustafsson,Keith R. Yamamoto +7 more
TL;DR: Five regions of MTV DNA that are bound specifically by purified receptor are mapped and compared, suggesting that receptor affinity for upstream and internal regions may differ by less than one order of magnitude.
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Persistent Activation of ERK Contributes to Glutamate-induced Oxidative Toxicity in a Neuronal Cell Line and Primary Cortical Neuron Cultures
Madalina Stanciu,Ying Wang,Ruth Kentor,Nancy V Burke,Simon C. Watkins,Geraldine J. Kress,Ian J. Reynolds,Eric Klann,Maria R. Angiolieri,Jon W. Johnson,Donald B. DeFranco +10 more
TL;DR: It is shown that delayed and persistent activation of ERKs is associated with glutamate-induced oxidative toxicity in HT22 cells and immature primary cortical neuron cultures, and that U0126, a specific inhibitor of the ERK-activating kinase, MEK-1/2, protects both HT22cells and immaturePrimary cortex neuron cultures from glutamate toxicity.
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International Union of Pharmacology. LXV. The Pharmacology and Classification of the Nuclear Receptor Superfamily: Glucocorticoid, Mineralocorticoid, Progesterone, and Androgen Receptors
Nick Z. Lu,Suzanne E. Wardell,Kerry L. Burnstein,Donald B. DeFranco,Peter J. Fuller,Vincent Giguère,Richard B. Hochberg,Lorraine I. McKay,Jack Michel Renoir,Nancy L. Weigel,Elizabeth M. Wilson,Donald P. McDonnell,John A. Cidlowski +12 more
TL;DR: Members of this subfamily are among those receptors that were cloned the earliest, with the exception of the glucocorticoid receptor, which has been cloned twice.
Journal ArticleDOI
Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement.
TL;DR: Evidence that dynamic assembly of heterocomplexes with hsp90 is required for movement to these foci and for the dynamic exchange of transcription factors between chromatin and the nucleoplasm is reviewed.
Journal ArticleDOI
Oxidative neuronal injury: The dark side of ERK1/2
Charleen T. Chu,David J. Levinthal,Scott M. Kulich,Elisabeth M. Chalovich,Donald B. DeFranco +4 more
TL;DR: It is proposed that differential accessibility of ERK1/2 to downstream targets, which is dictated by the persistent activation of ERk1/1 within distinct subcellular compartments, underlies the neurotoxic responses that are driven by this kinase.