D
Dong-In Koo
Researcher at Scripps Research Institute
Publications - 3
Citations - 491
Dong-In Koo is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Receptor & Immune system. The author has an hindex of 3, co-authored 3 publications receiving 420 citations.
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Journal ArticleDOI
Oxysterols direct immune cell migration via EBI2
Sébastien Hannedouche,Juan Zhang,Tangsheng Yi,Weijun Shen,Weijun Shen,Deborah Nguyen,João Pereira,Danilo Guerini,Birgit Baumgarten,Silvio Roggo,Ben Wen,Richard Knochenmuss,Sophie Noël,François Gessier,Lisa M. Kelly,Miroslava Vanek,Stephane Laurent,Inga Preuss,Charlotte Miault,Isabelle Christen,Ratnaningrum Karuna,Wei Li,Dong-In Koo,Thomas Suply,Christian Schmedt,Eric C. Peters,Rocco Falchetto,Andreas Katopodis,Carsten Spanka,Marie-Odile Roy,Michel Detheux,Yu Chen,Peter G. Schultz,Charles Y. Cho,Klaus Seuwen,Jason G. Cyster,Andreas W. Sailer +36 more
TL;DR: The identification of 7α,25-dihydroxycholesterol as a potent and selective agonist of EBI2 and its role in the adaptive immune response is described.
Journal ArticleDOI
Small Molecule Antagonists in Distinct Binding Modes Inhibit Drug-Resistant Mutant of Smoothened
Haiyan Tao,Qihui Jin,Dong-In Koo,Xuebin Liao,Nathan P. Englund,Yan Wang,Arun Ramamurthy,Peter G. Schultz,Marion Dorsch,Joseph Kelleher,Xu Wu,Xu Wu +11 more
TL;DR: These findings provide an insight of the ligand-binding sites of Smo and a basis for the development of potential therapeutics for tumors with drug-resistant Smo mutations.
Journal ArticleDOI
A Chemically Induced Vaccine Strategy for Prostate Cancer
Anna Dubrovska,Chan Hyuk Kim,Jimmy Elliott,Weijun Shen,Tun-Hsun Kuo,Dong-In Koo,Chun Li,Tove Tuntland,Jonathan Chang,Todd Groessl,Xu Wu,Vanessa Gorney,Teresa Ramirez-Montagut,David Spiegel,Charles Y. Cho,Peter G. Schultz +15 more
TL;DR: The ability to create a small molecule inducible antibody response against self-antigens using endogenous non-autoreactive antibodies may provide advantages over the autologous immune response generated by conventional vaccines in certain therapeutic settings.