Inga Preuss

TL;DR: The identification of 7α,25-dihydroxycholesterol as a potent and selective agonist of EBI2 and its role in the adaptive immune response is described.

TL;DR: The use of a series of studies that show G protein-coupled receptor-mediated biological activity of TLQP-21 signaling in CHO-K1 cells provides a bridge linking the regulation of metabolism and the activation of complement in rodents.

TL;DR: A role for EBI2 in astrocyte function is demonstrated for the first time and it is suggested that modulation of this receptor may be beneficial in neuroinflammatory disorders.

TL;DR: This is a study characterizing the oxysterol/EBI2 pathway in primary monocyte-derived macrophages, and showing that an induction of CH25H, CYP27A1, and CYP7B1 results in an enhanced production and release of oxysterols into the cellular environment.

TL;DR: The isolation of a potent small molecule antagonist for the EBI2 receptor is described and 4m is used to block migration of a monocyte cell line called U937, suggesting a functional role of the oxysterol/EBI2 pathway in these immune cells.