Birgit Baumgarten

TL;DR: The identification of 7α,25-dihydroxycholesterol as a potent and selective agonist of EBI2 and its role in the adaptive immune response is described.

TL;DR: The data suggest that endothelial cells sense local tissue acidosis via GPR4 and that this signal is required to generate a full angiogenic response to VEGF, and that G PR4 deficiency results in reduced VEGFR2 levels in endothelium, accounting for the observed phenotype.

TL;DR: The purification from porcine colonic tissue extracts of an agonistic ligand for GPR15 and its functional characterization identifies a receptor-ligand pair that is required for immune homeostasis at epithelia and whose modulation may represent an alternative approach to treating conditions affecting the skin such as psoriasis.

TL;DR: This is a study characterizing the oxysterol/EBI2 pathway in primary monocyte-derived macrophages, and showing that an induction of CH25H, CYP27A1, and CYP7B1 results in an enhanced production and release of oxysterols into the cellular environment.

TL;DR: Findings indicate that liposomes, in particular upon shell modification with phosphatidylserine, promote dexamethasone delivery to macrophages and induce a phenotype suitable to support chronic wound healing.