Rocco Falchetto

TL;DR: The identification of 7α,25-dihydroxycholesterol as a potent and selective agonist of EBI2 and its role in the adaptive immune response is described.

TL;DR: A lowest limit of quantification of 2 microg/mL HmAb was reached in both human and cynomolgus monkey samples, and the dynamic range of the method was 3 orders of magnitude.

TL;DR: A high-throughput screening methodology tailored to the discovery of ligands for known and orphan proteins is presented, as the ligands are affinity selected by incubation of the protein with mixtures of compounds in aqueous binding buffer.

TL;DR: It is speculated that specific inhibition of Jak3 is not sufficient to efficiently block γC cytokine signal transduction required for strong immunosuppression, and a synthetic approach toward the rapid modification of phenyl-indolyl maleimides and the discovery of potent Jak3 inhibitor 1 with high selectivity within the Jak kinase family is described.

TL;DR: The purification from porcine colonic tissue extracts of an agonistic ligand for GPR15 and its functional characterization identifies a receptor-ligand pair that is required for immune homeostasis at epithelia and whose modulation may represent an alternative approach to treating conditions affecting the skin such as psoriasis.