S
Sophie Noël
Researcher at Scripps Research Institute
Publications - 8
Citations - 463
Sophie Noël is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Immune receptor & G protein-coupled receptor. The author has an hindex of 4, co-authored 8 publications receiving 390 citations.
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Journal ArticleDOI
Oxysterols direct immune cell migration via EBI2
Sébastien Hannedouche,Juan Zhang,Tangsheng Yi,Weijun Shen,Weijun Shen,Deborah Nguyen,João Pereira,Danilo Guerini,Birgit Baumgarten,Silvio Roggo,Ben Wen,Richard Knochenmuss,Sophie Noël,François Gessier,Lisa M. Kelly,Miroslava Vanek,Stephane Laurent,Inga Preuss,Charlotte Miault,Isabelle Christen,Ratnaningrum Karuna,Wei Li,Dong-In Koo,Thomas Suply,Christian Schmedt,Eric C. Peters,Rocco Falchetto,Andreas Katopodis,Carsten Spanka,Marie-Odile Roy,Michel Detheux,Yu Chen,Peter G. Schultz,Charles Y. Cho,Klaus Seuwen,Jason G. Cyster,Andreas W. Sailer +36 more
TL;DR: The identification of 7α,25-dihydroxycholesterol as a potent and selective agonist of EBI2 and its role in the adaptive immune response is described.
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Optimization of Novel Antagonists to the Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part II)
Hamid R. Hoveyda,Graeme L. Fraser,Guillaume Dutheuil,Mohamed El Bousmaqui,Julien Korac,Francois Lenoir,Alexey Lapin,Sophie Noël +7 more
TL;DR: Overall, compound 3 emerged as the most efficacious in castrated rat and monkey to lower plasma LH, and it displayed the best off-target safety profile that led to its clinical candidate nomination for the treatment of sex-hormone disorders.
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Discovery and Optimization of Novel Antagonists to the Human Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part I)
Hamid R. Hoveyda,Graeme L. Fraser,Marie-Odile Roy,Guillaume Dutheuil,Frédéric Batt,Mohamed El Bousmaqui,Julien Korac,Francois Lenoir,Alexey Lapin,Sophie Noël,Sébastien Blanc +10 more
TL;DR: The discovery and lead optimization of a novel N-acyl-triazolopiperazine NK3R antagonist chemotype achieved through bioisosteric lead change from the high-throughput screening (HTS) hit is described.
Journal ArticleDOI
Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor.
Hamid R. Hoveyda,Marie-Odile Roy,Sébastien Blanc,Sophie Noël,Joseph M. Salvino,Mark A. Ator,Graeme Fraser +6 more
TL;DR: A series of 3-aryl-5-acylpiperazinyl-pyrazoles initially identified through a high-throughput screening campaign as novel, potent small molecule antagonists of the G protein-coupled human tachykinin NK(3) receptor (hNK3-R) is described.