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Weijun Shen
Researcher at Scripps Research Institute
Publications - 53
Citations - 1512
Weijun Shen is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Agonist & Receptor. The author has an hindex of 16, co-authored 50 publications receiving 1165 citations. Previous affiliations of Weijun Shen include Genomics Institute of the Novartis Research Foundation & State University of New York System.
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Journal ArticleDOI
Oxysterols direct immune cell migration via EBI2
Sébastien Hannedouche,Juan Zhang,Tangsheng Yi,Weijun Shen,Weijun Shen,Deborah Nguyen,João Pereira,Danilo Guerini,Birgit Baumgarten,Silvio Roggo,Ben Wen,Richard Knochenmuss,Sophie Noël,François Gessier,Lisa M. Kelly,Miroslava Vanek,Stephane Laurent,Inga Preuss,Charlotte Miault,Isabelle Christen,Ratnaningrum Karuna,Wei Li,Dong-In Koo,Thomas Suply,Christian Schmedt,Eric C. Peters,Rocco Falchetto,Andreas Katopodis,Carsten Spanka,Marie-Odile Roy,Michel Detheux,Yu Chen,Peter G. Schultz,Charles Y. Cho,Klaus Seuwen,Jason G. Cyster,Andreas W. Sailer +36 more
TL;DR: The identification of 7α,25-dihydroxycholesterol as a potent and selective agonist of EBI2 and its role in the adaptive immune response is described.
Journal ArticleDOI
Inhibition of DYRK1A and GSK3B induces human β-cell proliferation.
Weijun Shen,Brandon Taylor,Qihui Jin,Van Nguyen-Tran,Shelly Meeusen,You-Qing Zhang,Anwesh Kamireddy,Austin De Swafford,Andrew F. Powers,John P Walker,John Lamb,Badry Bursalaya,Michael DiDonato,George Harb,Minhua Qiu,Christophe M. Filippi,Lisa Deaton,Carolina N. Turk,Wilma L. Suarez-Pinzon,Yahu Liu,Xueshi Hao,Tingting Mo,Shanshan Yan,Jing-Jing Li,Ann E. Herman,Bernhard J. Hering,Tao Wu,H. Martin Seidel,Peter McNamara,Richard Glynne,Bryan Laffitte +30 more
TL;DR: The feasibility of treating diabetes with an oral therapy to restore β-cell mass is supported, a tractable pathway for future drug discovery efforts is highlighted, and Dyrk1a is highlighted as the key molecular target.
Journal ArticleDOI
Probing protein-protein interactions with a genetically encoded photo-crosslinking amino acid
TL;DR: It is reported that a new aminoacyl-tRNA synthetase engineered from wt-mbPylRS, when coupled with tRNA, can significantly increase the coding efficiency of AbK in both E. coli and mammalian cells.
Journal ArticleDOI
Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening
Weijun Shen,Matthew S. Tremblay,Matthew S. Tremblay,Matthew S. Tremblay,V. Deshmukh,Weidong Wang,Christophe M. Filippi,George Harb,You Qing Zhang,Anwesh Kamireddy,Janine E. Baaten,Qihui Jin,Tom Y.-H. Wu,Jonathan G. Swoboda,Charles Y. Cho,Jing Li,Bryan Laffitte,Peter McNamara,Richard Glynne,Xu Wu,Ann E. Herman,Peter G. Schultz,Peter G. Schultz +22 more
TL;DR: In the RIP-DTA mouse model of β cell ablation, WS6 normalized blood glucose and induced concomitant increases in β cell proliferation and β cell number and the discovery and characterization of WS6 is reported.