C
Carsten Spanka
Researcher at Novartis
Publications - 43
Citations - 1323
Carsten Spanka is an academic researcher from Novartis. The author has contributed to research in topics: Lewis acids and bases & Silylation. The author has an hindex of 14, co-authored 43 publications receiving 1182 citations. Previous affiliations of Carsten Spanka include Clausthal University of Technology.
Papers
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Journal ArticleDOI
Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase
Vito Guagnano,Pascal Furet,Carsten Spanka,Vincent Bordas,Mickaël Le Douget,Christelle Stamm,Josef Brueggen,Michael Rugaard Jensen,Christian Schnell,Herbert A. Schmid,Markus Wartmann,Joerg Berghausen,Peter Drueckes,Alfred Zimmerlin,Dirksen E. Bussiere,Jeremy Murray,Diana Graus Porta +16 more
TL;DR: In vivo evaluation of compound 1h showed significant antitumor activity in RT112 bladder cancer xenografts models overexpressing wild-type FGFR3 and support the potential therapeutic use of 1h as a new anticancer agent.
Journal ArticleDOI
Oxysterols direct immune cell migration via EBI2
Sébastien Hannedouche,Juan Zhang,Tangsheng Yi,Weijun Shen,Weijun Shen,Deborah Nguyen,João Pereira,Danilo Guerini,Birgit Baumgarten,Silvio Roggo,Ben Wen,Richard Knochenmuss,Sophie Noël,François Gessier,Lisa M. Kelly,Miroslava Vanek,Stephane Laurent,Inga Preuss,Charlotte Miault,Isabelle Christen,Ratnaningrum Karuna,Wei Li,Dong-In Koo,Thomas Suply,Christian Schmedt,Eric C. Peters,Rocco Falchetto,Andreas Katopodis,Carsten Spanka,Marie-Odile Roy,Michel Detheux,Yu Chen,Peter G. Schultz,Charles Y. Cho,Klaus Seuwen,Jason G. Cyster,Andreas W. Sailer +36 more
TL;DR: The identification of 7α,25-dihydroxycholesterol as a potent and selective agonist of EBI2 and its role in the adaptive immune response is described.
Patent
Pyrimidine urea derivatives as kinase inhibitors
Qiang Ding,Nathanael S. Gray,Bing Li,Yi Liu,Taebo Sim,Tetsuo Uno,Guobao Zhang,Pissot Soldermann Carole,Werner Breitenstein,Guido Bold,Giorgio Caravatti,Pascal Furet,Vito Guagnano,Marc Lang,Paul W. Manley,Joseph Schoepfer,Carsten Spanka +16 more
TL;DR: In this article, the authors defined compounds of formula (I) wherein the substituents X 1, R 1, R 2, R 3, R 4 and R 5 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity.
Journal ArticleDOI
A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets
Ye-Jin Hwang,Ye-Jin Hwang,Connor W. Coley,Milad Abolhasani,Andreas Marzinzik,Guido Koch,Carsten Spanka,Hansjoerg Lehmann,Klavs F. Jensen +8 more
TL;DR: An automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/ multi-phase and single/multi-step, with a reaction volume of just 14 μL is reported.
Journal ArticleDOI
N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase.
Zheng Yin,Yen Liang Chen,Ravinder Reddy Kondreddi,Wai Ling Chan,Gang Wang,Ru Hui Ng,Joanne Y.H. Lim,Wan Yen Lee,Duraiswamy Athisayamani Jeyaraj,Pornwaratt Niyomrattanakit,Daying Wen,Alex Chao,J. Fraser Glickman,Hans Voshol,Dieter Mueller,Carsten Spanka,Sigmar Dressler,Shahul Nilar,Subhash G. Vasudevan,Pei Yong Shi,Thomas H. Keller +20 more
TL;DR: A novel class of compounds containing N-sulfonylanthranilic acid was found to specifically inhibit dengue viral polymerase, and a preliminary structure-activity relationship is described.