D
Dorien Reijnders
Researcher at Louisiana State University
Publications - 22
Citations - 1262
Dorien Reijnders is an academic researcher from Louisiana State University. The author has contributed to research in topics: Gut flora & Insulin resistance. The author has an hindex of 8, co-authored 20 publications receiving 880 citations. Previous affiliations of Dorien Reijnders include Radboud University Nijmegen Medical Centre & Maastricht University Medical Centre.
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Journal ArticleDOI
Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity
A. Vrieze,Carolien Out,Susana Fuentes,Lisanne Jonker,Isaie J. Reuling,Ruud S. Kootte,Els van Nood,Frits Holleman,Max Knaapen,Johannes A. Romijn,Maarten R. Soeters,Ellen E. Blaak,Geesje M. Dallinga-Thie,Dorien Reijnders,Mariëtte T. Ackermans,Mireille J. Serlie,Filip K. Knop,Filip K. Knop,Jenst J. Holst,Claude van der Ley,Ido P. Kema,Erwin G. Zoetendal,Willem M. de Vos,Willem M. de Vos,Joost B. L. Hoekstra,Erik S.G. Stroes,Albert K. Groen,Max Nieuwdorp +27 more
TL;DR: Oral administration of vancomycin significantly impacts host physiology by decreasing intestinal microbiota diversity, bile acid dehydroxylation and peripheral insulin sensitivity in subjects with metabolic syndrome.
Journal ArticleDOI
Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial.
Dorien Reijnders,Gijs H. Goossens,Gerben D. A. Hermes,Evelien P. J. G. Neis,Christina M. van der Beek,Jasper Most,Jens J. Holst,Kaatje Lenaerts,Ruud S. Kootte,Max Nieuwdorp,Albert K. Groen,Steven W.M. Olde Damink,Mark V. Boekschoten,Hauke Smidt,Erwin G. Zoetendal,Cornelis H. C. Dejong,Ellen E. Blaak +16 more
TL;DR: Antibiotics did not affect tissue-specific insulin sensitivity, energy/substrate metabolism, postprandial hormones and metabolites, systemic inflammation, gut permeability, and adipocyte size, indicating that interference with adult microbiota by 7-day antibiotic treatment has no clinically relevant impact on metabolic health in obese humans.
Journal ArticleDOI
Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans
Mattea Müller,Manuel A. González Hernández,Gijs H. Goossens,Dorien Reijnders,Jens J. Holst,Johan W. E. Jocken,Hans M.H. van Eijk,Emanuel E. Canfora,Ellen E. Blaak +8 more
TL;DR: It is shown that circulating rather than faecal SCFA were associated with GLP-1 concentrations, whole-body lipolysis and peripheral IS in humans, which indicates the need to measure circulating SCFA in human prebiotic/probiotic intervention studies as a biomarker/mediator of effects on host metabolism.
Journal ArticleDOI
Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration
Henricus A. M. Mutsaers,Martijn J. Wilmer,Dorien Reijnders,Jitske Jansen,P.H.H. van den Broek,Marleen Forkink,Eva Schepers,Griet Glorieux,Raymond Vanholder,L.P.W.J. van den Heuvel,L.P.W.J. van den Heuvel,Joost G. J. Hoenderop,Rosalinde Masereeuw +12 more
TL;DR: This study shows that multiple uremic toxins inhibit UGT activity and mitochondrial activity in ciPTEC, thereby affecting the metabolic capacity of the kidney during CKD, and may have a significant impact on drug and Uremic retention solute disposition in CKD patients.
Journal ArticleDOI
Physical activity behaviour and screen time in Dutch children during the COVID-19 pandemic: Pre-, during- and post-school closures.
Gabrielle Ten Velde,Judith Lubrecht,Lisanne Arayess,Christiana van Loo,Marijn Hesselink,Dorien Reijnders,Anita Vreugdenhil +6 more
TL;DR: In this paper, the authors investigated the effect of COVID-19 measures on screen time and physical activity in Dutch children pre-, during-and post-school closures and found that children were less physically active and screen time was higher during and after the school closures due to the COVID19 lockdown.