C
Claude van der Ley
Researcher at University Medical Center Groningen
Publications - 10
Citations - 719
Claude van der Ley is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Farnesoid X receptor & Derivatization. The author has an hindex of 8, co-authored 10 publications receiving 513 citations. Previous affiliations of Claude van der Ley include University of Groningen.
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Journal ArticleDOI
Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity
A. Vrieze,Carolien Out,Susana Fuentes,Lisanne Jonker,Isaie J. Reuling,Ruud S. Kootte,Els van Nood,Frits Holleman,Max Knaapen,Johannes A. Romijn,Maarten R. Soeters,Ellen E. Blaak,Geesje M. Dallinga-Thie,Dorien Reijnders,Mariëtte T. Ackermans,Mireille J. Serlie,Filip K. Knop,Filip K. Knop,Jenst J. Holst,Claude van der Ley,Ido P. Kema,Erwin G. Zoetendal,Willem M. de Vos,Willem M. de Vos,Joost B. L. Hoekstra,Erik S.G. Stroes,Albert K. Groen,Max Nieuwdorp +27 more
TL;DR: Oral administration of vancomycin significantly impacts host physiology by decreasing intestinal microbiota diversity, bile acid dehydroxylation and peripheral insulin sensitivity in subjects with metabolic syndrome.
Journal ArticleDOI
Age- and Disease-Specific Changes of the Kynurenine Pathway in Parkinson's and Alzheimer's Disease
Freek J. H. Sorgdrager,Yannick Vermeiren,Yannick Vermeiren,Martijn van Faassen,Claude van der Ley,Ellen A. A. Nollen,Ido P. Kema,Peter Paul De Deyn,Peter Paul De Deyn +8 more
TL;DR: It is hypothesized that the combination of age‐ and disease‐specific changes in cerebral Kyn pathway activity could contribute to reduced neurogenesis and increased excitotoxicity in neurodegenerative disease.
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Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content
Lianmin Chen,Inge C.L. van den Munckhof,Kiki Schraa,Rob ter Horst,Martijn Koehorst,Martijn van Faassen,Claude van der Ley,Marwah Doestzada,Daria V. Zhernakova,Alexander Kurilshikov,Vincent W. Bloks,Albert K. Groen,Niels P. Riksen,Joost H.W. Rutten,Leo A. B. Joosten,Cisca Wijmenga,Alexandra Zhernakova,Mihai G. Netea,Jingyuan Fu,Folkert Kuipers +19 more
TL;DR: The study reveals genetic and microbial determinants of BAs in obesity and their relationship to disease-relevant lipid parameters that are important for the design of personalized therapies targeting BA-signaling pathways.
Journal ArticleDOI
In Matrix Derivatization Combined with LC-MS/MS Results in Ultrasensitive Quantification of Plasma Free Metanephrines and Catecholamines.
Martijn van Faassen,Rainer Bischoff,Karin Eijkelenkamp,Wilhelmina H. A. de Jong,Claude van der Ley,Ido P. Kema +5 more
TL;DR: This work shows that analytes in the subnanomolar range in plasma can be derivatized in situ without any preceding sample extraction and shows improved sensitivity and selectivity over existing methods and enables simultaneous quantification of several classes of amines.
Journal ArticleDOI
Repurposing Metformin in Nondiabetic People With HIV: Influence on Weight and Gut Microbiota.
Stéphane Isnard,Stéphane Isnard,John Lin,Brandon Fombuena,Jing Ouyang,Thibault V. Varin,Corentin Richard,André Marette,Rayoun Ramendra,Rayoun Ramendra,Delphine Planas,Laurence Raymond Marchand,Meriem Messaoudene,Claude van der Ley,Ido P. Kema,Darakhshan Sohail Ahmed,Yonglong Zhang,Malcolm Finkelman,Bertrand Routy,Jonathan B. Angel,Petronela Ancuta,Jean-Pierre Routy +21 more
TL;DR: This study provides the first evidence that a 12-week metformin treatment decreased weight and favored anti-inflammatory bacteria abundance in the microbiota of nondiabetic ART-treated PWH.