B
Bartomeu Colom
Researcher at Wellcome Trust Sanger Institute
Publications - 26
Citations - 1640
Bartomeu Colom is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Mitochondrion & TFAM. The author has an hindex of 13, co-authored 25 publications receiving 1303 citations. Previous affiliations of Bartomeu Colom include Queen Mary University of London & Carlos III Health Institute.
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Journal ArticleDOI
The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo
Abigail Woodfin,Mathieu-Benoit Voisin,Martina Beyrau,Bartomeu Colom,Dorothée Caille,Frantzeska-Maria Diapouli,Gerard B. Nash,Triantafyllos Chavakis,Steven M. Albelda,G. Ed Rainger,Paolo Meda,Beat A. Imhof,Sussan Nourshargh +12 more
TL;DR: The results identify JAM-C as a key regulator of polarized neutrophil TEM in vivo and suggest that reverse TEM of neutrophils can contribute to the dissemination of systemic inflammation.
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Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo
Bartomeu Colom,Jennifer V. Bodkin,Martina Beyrau,Abigail Woodfin,Christiane Ody,C Rourke,Triantafyllos Chavakis,Karim Brohi,Beat A. Imhof,Sussan Nourshargh +9 more
TL;DR: It is demonstrated that the lipid chemoattractant leukotriene B4 (LTB4) was efficacious at causing loss of venular JAM-C and promoting neutrophil reverse transendothelial cell migration (rTEM) in vivo.
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Caloric restriction and gender modulate cardiac muscle mitochondrial H2O2 production and oxidative damage
TL;DR: Higher mitochondrial differentiation becomes a metabolic adaptation to increase energy efficiency, as what happens in female and CR rats, which could help to understand the mechanism by which these animals exhibit a lower incidence of aging-related disorders, including cardiovascular disease.
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Endothelial Cell Junctional Adhesion Molecules: Role and Regulation of Expression in Inflammation.
TL;DR: Key aspects of the current understanding of the dynamics and mechanisms that regulate the expression of endothelial cells junctional molecules during inflammation are summarized and the associated functional implications of such events in acute and chronic scenarios are discussed.
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Sex-related differences in energy balance in response to caloric restriction
Adamo Valle,Antoni Català-Niell,Bartomeu Colom,Francisco J. García-Palmer,Jordi Oliver,Pilar Roca +5 more
TL;DR: It is indicated that females under caloric restriction conditions deactivate facultative thermogenesis to a greater degree than males, which may have obvious advantages for female survival and therefore the survival of the species when food is limiting.