Dorothee Harbecke

TL;DR: Exploiting the unique Strongyloides life cycle, the transcriptomes of the parasitic and free-living stages are compared and it is found that these same gene families are upregulated in the parasitic stages, underscoring their role in nematode parasitism.

TL;DR: It is reported that infection of quiescent murine M ϕ with L. mexicana or L. major amastigotes does not induce IL‐12 production and Mϕ effector functions are differentially affected and this may be a general effect of phagocytosis of non‐activating particles.

TL;DR: In mouse infection studies, the spontaneous L. mexicana repeat-deficient mutant and theΔlmexlpg2 mutant showed no significant difference to a wild type strain with respect to the severity of disease caused by these parasites, suggesting that at least in Leishmania mexICana, PG repeat synthesis is not an absolute requirement for virulence.

TL;DR: The kinetics of the two waves suggests that DC turnover has an important impact on antigen presentation during infections with complex pathogens, and argues against a relevant genetic difference in the DC initiating the anti‐parasite Th cell response in these mice.

TL;DR: The mAbs are used to characterize changes in lipophosphoglycan structure, which occur in culture during the transition of promastigotes from the logarithmic to the stationary growth phase, and suggest the presence of capped phosphosaccharide repeats while the enzymically active glycoprotein subunit is modified by caps but probably not by repeats.