K
Karen Brooks
Researcher at Wellcome Trust Sanger Institute
Publications - 30
Citations - 12308
Karen Brooks is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 23, co-authored 30 publications receiving 11583 citations. Previous affiliations of Karen Brooks include Wellcome Trust.
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Journal ArticleDOI
The genome sequence of Schizosaccharomyces pombe
Valerie Wood,R. Gwilliam,Marie-Adèle Rajandream,M. Lyne,Rachel Lyne,A. Stewart,J. Sgouros,N. Peat,Jacqueline Hayles,Stephen Baker,D. Basham,Sharen Bowman,Karen Brooks,D. Brown,Steve D.M. Brown,Tracey Chillingworth,Carol Churcher,Mark O. Collins,R. Connor,Ann Cronin,P. Davis,Theresa Feltwell,Andrew G. Fraser,S. Gentles,Arlette Goble,N. Hamlin,David Harris,J. Hidalgo,Geoffrey M. Hodgson,S. Holroyd,T. Hornsby,S. Howarth,Elizabeth J. Huckle,Sarah E. Hunt,Kay Jagels,Kylie R. James,L. Jones,Matthew Jones,S. Leather,S. McDonald,J. McLean,P. Mooney,Sharon Moule,Karen Mungall,Lee Murphy,D. Niblett,C. Odell,Karen Oliver,Susan O'Neil,D. Pearson,Michael A. Quail,Ester Rabbinowitsch,Kim Rutherford,Simon Rutter,David L. Saunders,Kathy Seeger,Sarah Sharp,Jason Skelton,Mark Simmonds,R. Squares,S. Squares,K. Stevens,K. Taylor,Ruth Taylor,Adrian Tivey,S. Walsh,T. Warren,S. Whitehead,John Woodward,Guido Volckaert,Rita Aert,Johan Robben,B. Grymonprez,I. Weltjens,E. Vanstreels,Michael A. Rieger,M. Schafer,S. Muller-Auer,C. Gabel,M. Fuchs,C. Fritzc,E. Holzer,D. Moestl,H. Hilbert,K. Borzym,I. Langer,Alfred Beck,Hans Lehrach,Richard Reinhardt,Thomas M. Pohl,P. Eger,Wolfgang Zimmermann,H. Wedler,R. Wambutt,Bénédicte Purnelle,André Goffeau,Edouard Cadieu,Stéphane Dréano,Stéphanie Gloux,Valerie Lelaure,Stéphanie Mottier,Francis Galibert,Stephen J. Aves,Z. Xiang,Cherryl Hunt,Karen Moore,S. M. Hurst,M. Lucas,M. Rochet,Claude Gaillardin,Victor A. Tallada,Victor A. Tallada,Andrés Garzón,Andrés Garzón,G. Thode,Rafael R. Daga,Rafael R. Daga,L. Cruzado,Juan Jimenez,Juan Jimenez,Miguel del Nogal Sánchez,F. del Rey,J. Benito,Angel Domínguez,José L. Revuelta,Sergio Moreno,John Armstrong,Susan L. Forsburg,L. Cerrutti,Todd M. Lowe,W. R. McCombie,Ian T. Paulsen,Judith A. Potashkin,G. V. Shpakovski,David W. Ussery,Bart Barrell,Paul Nurse +136 more
TL;DR: The genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote, is sequenced and highly conserved genes important for eukARYotic cell organization including those required for the cytoskeleton, compartmentation, cell-cycle control, proteolysis, protein phosphorylation and RNA splicing are identified.
Journal ArticleDOI
The Genome of the African Trypanosome Trypanosoma brucei
Matthew Berriman,Elodie Ghedin,Elodie Ghedin,Christiane Hertz-Fowler,Gaëlle Blandin,Hubert Renauld,Daniella Castanheira Bartholomeu,Nicola Lennard,Elisabet Caler,N. Hamlin,Brian J. Haas,Ulrike Böhme,Linda Hannick,Martin Aslett,Joshua Shallom,Lucio Marcello,Lihua Hou,Bill Wickstead,U. Cecilia M. Alsmark,Claire Arrowsmith,Rebecca Atkin,Andrew Barron,Frédéric Bringaud,Karen Brooks,Mark Carrington,Inna Cherevach,Tracey-Jane Chillingworth,Carol Churcher,Louise Clark,Craig Corton,Ann Cronin,Robert L. Davies,Jonathon Doggett,Appolinaire Djikeng,Tamara Feldblyum,Mark C. Field,Audrey Fraser,Ian Goodhead,Zahra Hance,David Harper,Barbara Harris,Heidi Hauser,Jessica B. Hostetler,Al Ivens,Kay Jagels,David W. Johnson,Justin Johnson,Kristine Jones,Arnaud Kerhornou,Hean Koo,Natasha Larke,Scott M. Landfear,Christopher Larkin,Vanessa Leech,Alexandra Line,Angela Lord,Annette MacLeod,P. Mooney,Sharon Moule,David M. A. Martin,Gareth W. Morgan,Karen Mungall,Halina Norbertczak,Doug Ormond,Grace Pai,Christopher S. Peacock,Jeremy Peterson,Michael A. Quail,Ester Rabbinowitsch,Marie-Adèle Rajandream,Chris P Reitter,Steven L. Salzberg,Mandy Sanders,Seth Schobel,Sarah Sharp,Mark Simmonds,Anjana J. Simpson,Luke J. Tallon,C. Michael R. Turner,Andrew Tait,Adrian Tivey,Susan Van Aken,Danielle Walker,David Wanless,Shiliang Wang,Brian White,Owen White,Sally Whitehead,John Woodward,Jennifer R. Wortman,Mark Raymond Adams,T. Martin Embley,Keith Gull,Elisabetta Ullu,J. David Barry,Alan H. Fairlamb,Fred R. Opperdoes,Barclay G. Barrell,John E. Donelson,Neil Hall,Neil Hall,Claire M. Fraser,Sara E. Melville,Najib M. El-Sayed,Najib M. El-Sayed +104 more
TL;DR: Comparisons of the cytoskeleton and endocytic trafficking systems of Trypanosoma brucei with those of humans and other eukaryotic organisms reveal major differences.
Journal ArticleDOI
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
Julian Parkhill,Gordon Dougan,Keith D. James,Nicholas R. Thomson,Derek Pickard,John Wain,Carol Churcher,Karen Mungall,Stephen D. Bentley,Matthew T. G. Holden,Mohammed Sebaihia,Stephen Baker,D. Basham,Karen Brooks,Tracey Chillingworth,Phillippa L. Connerton,A. Cronin,P. Davis,Robert L. Davies,L. Dowd,Nicholas J. White,Jeremy Farrar,Theresa Feltwell,N. Hamlin,Ashraful Haque,Tran Tinh Hien,S. Holroyd,Kay Jagels,Anders Krogh,Torben Larsen,S. Leather,Sharon Moule,Peadar O'Gaora,Christopher M. Parry,Michael A. Quail,Kim Rutherford,Mark Simmonds,Jason Skelton,K. Stevens,Sally Whitehead,Bart Barrell +40 more
TL;DR: The genome sequence is sequenced of a S. typhi (CT18) that is resistant to multiple drugs, revealing the presence of hundreds of insertions and deletions compared with the Escherichia coli genome, ranging in size from single genes to large islands.
Journal ArticleDOI
Genome sequence of Yersinia pestis , the causative agent of plague
Julian Parkhill,Brendan W. Wren,Nicholas R. Thomson,Richard W. Titball,Matthew T. G. Holden,Michael B. Prentice,Mohammed Sebaihia,Keith D. James,Carol Churcher,Karen Mungall,Stephen Baker,D. Basham,Stephen D. Bentley,Karen Brooks,Ana Cerdeño-Tárraga,Tracey Chillingworth,A. Cronin,Robert L. Davies,P. Davis,Gordon Dougan,Theresa Feltwell,N. Hamlin,S. Holroyd,Kay Jagels,Andrey V. Karlyshev,S. Leather,Sharon Moule,P. C. F. Oyston,Michael A. Quail,Kim Rutherford,Mark Simmonds,Jason Skelton,K. Stevens,Sally Whitehead,Bart Barrell +34 more
TL;DR: The evidence of ongoing genome fluidity, expansion and decay suggests Y. pestis is a pathogen that has undergone large-scale genetic flux and provides a unique insight into the ways in which new and highly virulent pathogens evolve.
Journal ArticleDOI
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
Mohammed Sebaihia,Brendan W. Wren,Peter Mullany,Neil F. Fairweather,Nigel P. Minton,Richard A. Stabler,Nicholas R. Thomson,Adam P. Roberts,Ana Cerdeño-Tárraga,Hongmei Wang,Matthew T. G. Holden,Anne Wright,Carol Churcher,Michael A. Quail,Stephen Baker,Nathalie Bason,Karen Brooks,Tracey Chillingworth,Ann Cronin,Paul Davis,Linda Dowd,Audrey Fraser,Theresa Feltwell,Zahra Hance,S. Holroyd,Kay Jagels,Sharon Moule,Karen Mungall,Claire Price,Ester Rabbinowitsch,Sarah Sharp,Mark Simmonds,K. Stevens,Louise Unwin,Sally Whithead,Bruno Dupuy,Gordon Dougan,Bart Barrell,Julian Parkhill +38 more
TL;DR: The complete genome sequence of Clostridium difficile strain 630, a virulent and multidrug-resistant strain, is determined; it indicates that a large proportion (11%) of the genome consists of mobile genetic elements, mainly in the form of conjugative transposons.