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Isheng J. Tsai
Researcher at Academia Sinica
Publications - 81
Citations - 6452
Isheng J. Tsai is an academic researcher from Academia Sinica. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 26, co-authored 66 publications receiving 5468 citations. Previous affiliations of Isheng J. Tsai include Imperial College London & Wellcome Trust Sanger Institute.
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Journal ArticleDOI
Population genomics of domestic and wild yeasts
Gianni Liti,David M. Carter,Alan M. Moses,Alan M. Moses,Jonas Warringer,Leopold Parts,Stephen A. James,Robert P. Davey,Ian N. Roberts,Austin Burt,Vassiliki Koufopanou,Isheng J. Tsai,Casey M. Bergman,Douda Bensasson,Michael J. T. O’Kelly,Alexander van Oudenaarden,David B. H. Barton,Elizabeth Bailes,Alex N. Nguyen,Matthew Jones,Michael A. Quail,Ian Goodhead,Ian Goodhead,Sarah Sims,Frances Smith,Anders Blomberg,Richard Durbin,Edward J. Louis +27 more
TL;DR: Rather than one or two domestication events leading to the extant baker’s yeasts, the population structure of S. cerevisiae consists of a few well-defined, geographically isolated lineages and many different mosaics of these lineages, supporting the idea that human influence provided the opportunity for cross-breeding and production of new combinations of pre-existing variations.
Journal ArticleDOI
The genomes of four tapeworm species reveal adaptations to parasitism
Isheng J. Tsai,Magdalena Zarowiecki,Nancy Holroyd,Alejandro Garciarrubio,Alejandro Sanchez-Flores,Karen Brooks,Alan Tracey,Raúl J. Bobes,Gladis Fragoso,Edda Sciutto,Martin Aslett,Helen Beasley,Hayley M. Bennett,Jianping Cai,Federico Camicia,Richard Clark,Marcela Alejandra Cucher,Nishadi De Silva,Tim A. Day,Peter Deplazes,Karel Estrada,Cecilia Fernández,Peter W. H. Holland,Junling Hou,Songnian Hu,Thomas Huckvale,Stacy S. Hung,Laura Kamenetzky,Jacqueline A. Keane,Ferenc Kiss,Uriel Koziol,Olivia Lambert,Kan Liu,Xuenong Luo,Yingfeng Luo,Natalia Macchiaroli,Sarah Nichol,Jordi Paps,John Parkinson,Natasha Pouchkina-Stantcheva,Nick Riddiford,Mara Cecilia Rosenzvit,Gustavo Salinas,James D. Wasmuth,Mostafa Zamanian,Yadong Zheng,Xuepeng Cai,Xavier Soberón,Peter D. Olson,Juan Pedro Laclette,Klaus Brehm,Matthew Berriman +51 more
TL;DR: An analysis of tapeworm genome sequences using the human-infective species Echinococcus multilocularis, E. granulosus, Taenia solium and the laboratory model Hymenolepis microstoma offers insights into the evolution of parasitism and identifies new potential drug targets.
Journal ArticleDOI
A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni.
Anna V. Protasio,Isheng J. Tsai,A K Babbage,Sarah Nichol,Martin Hunt,Martin Aslett,Nishadi De Silva,Giles S. Velarde,Tim J. Anderson,Richard Clark,Claire Davidson,Gary P. Dillon,Nancy Holroyd,Philip T. LoVerde,Christine Lloyd,Jacquelline McQuillan,Guilherme Oliveira,Thomas D. Otto,Sophia J. Parker-Manuel,Michael A. Quail,R. Alan Wilson,Adhemar Zerlotini,David W. Dunne,Matthew Berriman +23 more
TL;DR: The upgraded genome of Schistosoma mansoni will form a fundamental dataset to underpin further advances in schistosome research and is consolidated into a searchable format within the GeneDB and SchistoDB databases.
Journal ArticleDOI
Population genomics of domestic and wild yeasts
David M. Carter,Gianni Liti,Alan M. Moses,Leopold Parts,Stephen A. James,Robert P. Davey,Ian N. Roberts,Anders Blomberg,Jonas Warringer,Austin Burt,Vassiliki Koufopanou,Isheng J. Tsai,Casey M. Bergman,Douda Bensasson,Michael J. T. O’Kelly,Alexander van Oudenaarden,David B. H. Barton,Elizabeth Bailes,Matthew Jones,Michael A. Quail,Ian Goodhead,Sarah Sims,Frances Smith,Richard Durbin,Edward J. Louis +24 more
TL;DR: Rather than one or two domestication events leading to the extant baker's yeasts, the population structure of S. cerevisiae shows a few well defined geographically isolated lineages and many different mosaics of these lineages, supporting the notion that human influence provided the opportunity for outbreeding and production of new combinations of pre-existing variation.
Journal ArticleDOI
Genomic insights into the origin of parasitism in the emerging plant pathogen Bursaphelenchus xylophilus.
Taisei Kikuchi,James Cotton,Jonathan J. Dalzell,Koichi Hasegawa,Natsumi Kanzaki,Paul McVeigh,Takuma Takanashi,Isheng J. Tsai,Samuel Assefa,Peter J. A. Cock,Thomas D. Otto,Martin Hunt,Adam J. Reid,Alejandro Sanchez-Flores,Kazuko Tsuchihara,Toshiro Yokoi,Mattias C. Larsson,Mattias C. Larsson,Johji Miwa,Aaron G. Maule,Norio Sahashi,John T. Jones,Matthew Berriman +22 more
TL;DR: A high-quality draft genome sequence from an inbred line of B. xylophilus is presented, and the lack of proteins homologous to effectors from other plant parasitic nematodes confirms the distinctive molecular basis of plant parasitism in the Bursaphelenchus lineage.