D
Dorothy E. Patton
Researcher at International Life Sciences Institute
Publications - 5
Citations - 840
Dorothy E. Patton is an academic researcher from International Life Sciences Institute. The author has contributed to research in topics: Mode of action & Risk assessment. The author has an hindex of 5, co-authored 5 publications receiving 804 citations. Previous affiliations of Dorothy E. Patton include Washington University in St. Louis.
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Journal ArticleDOI
A framework for human relevance analysis of information on carcinogenic modes of action.
M. E. Meek,John R. Bucher,Samuel M. Cohen,Vicki L. Dellarco,Richard N. Hill,Lois D. Lehman-McKeeman,David G. Longfellow,Timothy P. Pastoor,Jennifer Seed,Dorothy E. Patton +9 more
TL;DR: By providing a systematic approach to using MOA data, the HRF offers a new tool for the scientific community's overall effort to enhance the predictive power, reliability and transparency of cancer risk assessment.
Journal ArticleDOI
Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity data.
Jennifer Seed,Edward W. Carney,Richard A. Corley,Kevin M. Crofton,John M. DeSesso,Paul M. D. Foster,Robert J. Kavlock,Gary L. Kimmel,James E. Klaunig,M. E. Meek,R. Julian Preston,William Slikker,Sonia Tabacova,Gary M. Williams,Jeanette A Wiltse,R. Thomas Zoeller,Penelope A. Fenner-Crisp,Dorothy E. Patton +17 more
TL;DR: The HRF features a “concordance” analysis of MOA information from both animal and human sources, with a focus on determining the appropriate role for each MOA data set in human risk assessment.
Journal ArticleDOI
Evaluating the human relevance of chemically induced animal tumors.
Samuel M. Cohen,James E. Klaunig,M. Elizabeth Meek,Richard N. Hill,Timothy P. Pastoor,Lois D. Lehman-McKeeman,John R. Bucher,David G. Longfellow,Jennifer Seed,Vicki L. Dellarco,Penelope A. Fenner-Crisp,Dorothy E. Patton +11 more
TL;DR: This FORUM paper features a systematic analysis for using mode of action information from animal and human studies, based in part on case examples involving environmental chemicals and pharmaceuticals.
Journal ArticleDOI
The Human Relevance of Information on Carcinogenic Modes of Action: Overview
TL;DR: The case studies in these reports present models for using MOA information to evaluate the hazard potential for humans and illustrate the substantial impact of a complete human relevance analysis, as distinct from an animal MOA analysis alone, on the nature and scope of risk assessment.
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Scientific peer review to inform regulatory decision making: leadership responsibilities and cautions.
TL;DR: Insight is offered on the peer-review process as it relates to scientific and technical reports used to inform regulatory decisions and nine fundamental "leadership responsibilities" that determine the nature and course of peer review are highlighted.