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Dorthe Helena Larsen
Researcher at University of Copenhagen
Publications - 22
Citations - 2561
Dorthe Helena Larsen is an academic researcher from University of Copenhagen. The author has contributed to research in topics: DNA damage & Chromatin. The author has an hindex of 12, co-authored 15 publications receiving 2207 citations. Previous affiliations of Dorthe Helena Larsen include University of Zurich & Wageningen University and Research Centre.
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Journal ArticleDOI
RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins
Carsten Doil,Niels Mailand,Simon Bekker-Jensen,Patrice Menard,Dorthe Helena Larsen,Rainer Pepperkok,Jan Ellenberg,Stephanie Panier,Daniel Durocher,Jiri Bartek,Jiri Lukas,Claudia Lukas +11 more
TL;DR: Evidence is provided that, while RNF8 is necessary to trigger the DSB-associated ubiquitylation, it is not sufficient to sustain conjugated ubiquitin in this compartment, which defines a new pathway involving sequential ubiquitylations on damaged chromosomes and uncovers a functional cooperation between E3 ligases in genome maintenance.
Journal ArticleDOI
ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA
Luis I. Toledo,Matthias Altmeyer,Maj-Britt Rask,Claudia Lukas,Dorthe Helena Larsen,Lou Klitgaard Povlsen,Simon Bekker-Jensen,Niels Mailand,Jiri Bartek,Jiri Lukas +9 more
TL;DR: ATR-mediated suppression of dormant origins shields active forks against irreversible breakage via preventing exhaustion of nuclear RPA, elucidates how replicating genomes avoid destabilizing DNA damage and provides a molecular rationale for their hypersensitivity to ATR inhibitors.
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Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response
Martin V. Bennetzen,Dorthe Helena Larsen,Jakob Bunkenborg,Jiri Bartek,Jiri Lukas,Jens S. Andersen +5 more
TL;DR: The data extend the number of known phosphorylation sites regulated by DNA damage, provides so far unprecedented temporal dissection of DNA damage-modifiedosphorylation events, and elucidate the cross-talk between different types of post-translational modifications in the dynamic regulation of a multifaceted DNA damage response.
Journal ArticleDOI
The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage
Dorthe Helena Larsen,Catherine Poinsignon,Thorkell Gudjonsson,Christoffel Dinant,Mark R. Payne,Flurina J. Hari,Jannie Rendtlew Danielsen,Patrice Menard,Jette Christensen Sand,Manuel Stucki,Claudia Lukas,Jiri Bartek,Jens S. Andersen,Jiri Lukas +13 more
TL;DR: The CHD4 helicase is identified as a new component of the genome surveillance machinery in a proteomic screen for factors enriched on chromatin after ionizing radiation.
Journal ArticleDOI
The NBS1–Treacle complex controls ribosomal RNA transcription in response to DNA damage
Dorthe Helena Larsen,Flurina J. Hari,Julie A. Clapperton,Myriam Gwerder,Katrin Gutsche,Matthias Altmeyer,Stephanie Jungmichel,Luis I. Toledo,Daniel Fink,Maj-Britt Rask,Merete Grøfte,Claudia Lukas,Michael L. Nielsen,Stephen J. Smerdon,Jiri Lukas,Manuel Stucki +15 more
TL;DR: An in trans signalling mechanism that triggers pan-nuclear silencing of rRNA transcription in response to DNA damage is discovered that is associated with transient recruitment of the Nijmegen breakage syndrome protein 1 (NBS1), a central regulator of DNA damage responses, into the nucleoli.