D
Douglas V. Dolfi
Researcher at University of Pennsylvania
Publications - 15
Citations - 2281
Douglas V. Dolfi is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 14, co-authored 15 publications receiving 1951 citations. Previous affiliations of Douglas V. Dolfi include Wistar Institute & Drexel University.
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Journal ArticleDOI
Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.
Michael A. Paley,Daniela C. Kroy,Pamela M. Odorizzi,Jonathan B. Johnnidis,Douglas V. Dolfi,Burton E. Barnett,Elizabeth K. Bikoff,Elizabeth J. Robertson,Georg M. Lauer,Steven L. Reiner,E. John Wherry +10 more
TL;DR: It is demonstrated that the T-box transcription factors T-bet and Eomesodermin differentially regulate two phenotypically and functionally distinct subsets of antiviral CD8+ T cells in mice, which may be important for antiviral immunity during chronic viral infections in humans.
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Transcriptional analysis of HIV-specific CD8 + T cells shows that PD-1 inhibits T cell function by upregulating BATF
Michael Quigley,Florencia Pereyra,Björn Nilsson,Filippos Porichis,Catia Fonseca,Quentin Eichbaum,Boris Julg,Jonathan L. Jesneck,Jonathan L. Jesneck,Kathleen Brosnahan,Sabrina Imam,Kate Russell,Ildiko Toth,Alicja Piechocka-Trocha,Douglas V. Dolfi,Jill M. Angelosanto,Alison Crawford,Haina Shin,Douglas S. Kwon,Jennifer Zupkosky,Loise M. Francisco,Gordon J. Freeman,E. John Wherry,Daniel Kaufmann,Daniel Kaufmann,Bruce D. Walker,Benjamin L. Ebert,Benjamin L. Ebert,Benjamin L. Ebert,W. Nicholas Haining +29 more
TL;DR: It is shown that PD-1 coordinately upregulates a program of genes in exhausted CD8+ T cells from humans and mice that includes upregulation of basic leucine transcription factor, ATF-like (BATF), a transcription factor in the AP-1 family that inhibit T cell function.
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Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor–Transduced Human T cells in Solid Tumors
Edmund K. Moon,Liang-Chuan Wang,Douglas V. Dolfi,Caleph B. Wilson,Raghuveer Ranganathan,Jing Sun,Veena Kapoor,John Scholler,Ellen Puré,Michael C. Milone,Carl H. June,James L. Riley,E. John Wherry,Steven M. Albelda +13 more
TL;DR: The results suggest that PD1 pathway antagonism may augment human CAR T-cell function, and will be an important tool for testing T cell–based strategies or systemic approaches to overcome this tumor-induced inhibition.
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Circulating CXCR5+PD-1+ Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults
Ramin S. Herati,Morgan A. Reuter,Douglas V. Dolfi,Kathleen D. Mansfield,Htin Aung,Osama Z. Badwan,Raj K. Kurupati,S. Kannan,Hildegund C.J. Ertl,Kenneth E. Schmader,Michael R. Betts,David H. Canaday,E. John Wherry +12 more
TL;DR: Future rational vaccine design efforts should incorporate Tfh measurement as an immune correlate of protection, particularly in the setting of aging.
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Perforin and IL-2 Upregulation Define Qualitative Differences among Highly Functional Virus-Specific Human CD8(+) T Cells
George Makedonas,Natalie A. Hutnick,Danielle Haney,Alexandra C. Amick,Jay Gardner,Gabriela L. Cosma,Adam R. Hersperger,Douglas V. Dolfi,E. John Wherry,Guido Ferrari,Michael R. Betts +10 more
TL;DR: “polyfunctional” profiling of antigen-specific CD8+ T cells must not be limited to simply the number of functions the cell can perform, or one particular memory phenotype, but should actually define which combinations of memory markers and functions are relevant in each pathogenic context.