D
Dun Xian Tan
Researcher at University of Texas Health Science Center at San Antonio
Publications - 315
Citations - 47893
Dun Xian Tan is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Melatonin & Oxidative stress. The author has an hindex of 117, co-authored 308 publications receiving 42258 citations. Previous affiliations of Dun Xian Tan include University of Texas System & University of Texas at Austin.
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Journal ArticleDOI
Melatonin ameliorates neurologic damage and neurophysiologic deficits in experimental models of stroke.
R. J. Reiter,Rosa M. Sainz,Silvia Lopez-Burillo,Juan C. Mayo,Lucien C. Manchester,Dun Xian Tan +5 more
TL;DR: Melatonin was universally found to reduce brain damage that normally occurs as a consequence of the temporary interruption of blood flow followed by the reflow of oxygenated blood to the brain, suggesting that even physiologic concentrations of melatonin normally serve to protect the brain against damage.
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Protective effects of melatonin against oxidation of guanine bases in DNA and decreased microsomal membrane fluidity in rat liver induced by whole body ionizing radiation.
Malgorzata Karbownik,Russel J. Reiter,Wenbo Qi,Joaquin J. Garcia,Dun Xian Tan,Lucien C. Manchester,Vijayalaxmi +6 more
TL;DR: Changes in 8-OH-dG levels and membrane fluidity are early sensitive parameters of DNA and microsomal membrane damage, respectively, induced by ionizing radiation and the findings document the protective effects of melatonin against ionizing Radiation.
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Cyclic 3-hydroxymelatonin: a melatonin metabolite generated as a result of hydroxyl radical scavenging.
TL;DR: When exogenous melatonin was administered to young rats, urinary 3-OHM levels increased significantly in the treated rats compared to those in controls, indicating that even in young animals there is insufficient endogenously produced melatonin to detoxify the basal levels of the toxic HO·.
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Ebola virus disease: potential use of melatonin as a treatment
TL;DR: Melatonin has a high safety profile, is readily available and can be orally self‐administered; thus, the use of melatonin is compatible with the large scale of this serious outbreak.
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Clinical relevance of melatonin in ovarian and placental physiology: a review
TL;DR: The findings that melatonin protects the oocyte from toxic oxygen species have implications for improving the outcome of in vitro fertilization–embryo transfer procedures and the use of melatonin to treat preeclampsia should also be considered.