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Dun Xian Tan
Researcher at University of Texas Health Science Center at San Antonio
Publications - 315
Citations - 47893
Dun Xian Tan is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Melatonin & Oxidative stress. The author has an hindex of 117, co-authored 308 publications receiving 42258 citations. Previous affiliations of Dun Xian Tan include University of Texas System & University of Texas at Austin.
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Journal ArticleDOI
Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics.
TL;DR: Melatonin protects mitochondria by scavenging reactive oxygen species (ROS), inhibiting the mitochondrial permeability transition pore (MPTP), and activating uncoupling proteins (UCPs) and maintains the optimal mitochondrial membrane potential and preserves mitochondrial functions.
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Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole
Dun Xian Tan,Russel J. Reiter,Li Dun Chen,Burkhard Poeggeler,Lucien C. Manchester,Lornell Barlow-Walden +5 more
TL;DR: Melatonin's ability to suppress DNA adduct formation may relate to its inhibitory effect on a mixed function oxidase, cytochrome p-450, and on the recently identified hydroxyl radical scavenging capacity of the indole.
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N1-acetyl-N2-formyl-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant
Dun Xian Tan,Lucien C. Manchester,Susanne Burkhardt,Rosa M. Sainz,Juan C. Mayo,Ronnie Kohen,Esther Shohami,Yu-Shu Huo,Rüdiger Hardeland,Russel J. Reiter +9 more
TL;DR: AFMK is a naturally occurring molecule with potent free radical scavenging capacity (donating two electrons/molecule) and thus may be a valuable new antioxidant for preventing and treating free radical‐related disorders.
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Melatonin in Chinese medicinal herbs.
TL;DR: The current study provides new information concerning one potentially effective constituent present in a large number of medicinal herbs and suggests that these herbs should be reevaluated in reference to their nutritional and medicinal value.
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Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin.
Sergio Rosales-Corral,Darío Acuña-Castroviejo,Ana Coto-Montes,José Antonio Boga,Lucien C. Manchester,Lorena Fuentes-Broto,Ahmet Korkmaz,Shuran Ma,Dun Xian Tan,Russel J. Reiter +9 more
TL;DR: The intent of this review is to stimulate interest in melatonin as a potentially useful agent in attenuating and/or delaying AD.