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Dun Xian Tan
Researcher at University of Texas Health Science Center at San Antonio
Publications - 315
Citations - 47893
Dun Xian Tan is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Melatonin & Oxidative stress. The author has an hindex of 117, co-authored 308 publications receiving 42258 citations. Previous affiliations of Dun Xian Tan include University of Texas System & University of Texas at Austin.
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Journal ArticleDOI
Effects of Melatonin on the Proliferation and Apoptosis of Sheep Granulosa Cells under Thermal Stress
Yao Fu,Chang Jiu He,Peng Yun Ji,Zhi Yong Zhuo,Xiu Zhi Tian,Feng Wang,Dun Xian Tan,Guoshi Liu +7 more
TL;DR: Evidence for the molecular mechanisms of the protective effects of melatonin on granulosa cells during thermal stress is provided and mechanistic exploration indicated that melatonin down-regulated p53 and up-regulated Bcl-2 and LHR gene expression of granul Rosa cells under thermal stress.
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Circadian mechanisms in the regulation of melatonin synthesis: disruption with light at night and the pathophysiological consequences -
Russel J. Reiter,Dun Xian Tan,Emilio J. Sánchez-Barceló,M. D. Mediavilla,Eloisa Gitto,Ahmet Korkmaz +5 more
TL;DR: The processes by which light after darkness onset impedes melatonin production and disturbs circadian rhythms are summarized and it seems likely that cancer will not be the exclusive pathophysiological change associated with the rampant light pollution characteristic of modern societies.
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Reactive oxygen species and the hypomotility of the gall bladder as targets for the treatment of gallstones with melatonin: a review
Sreedevi Koppisetti,Bharat Jenigiri,M. Pilar Terron,Sandra Tengattini,Hiroshi Tamura,Luis J. Flores,Dun Xian Tan,Russel J. Reiter +7 more
TL;DR: Up-to-date information on the pathophysiology of the gall bladder function is reviewed and the development of new therapies with potential good patient compliance and lower cost than the current treatments are discussed.
Journal ArticleDOI
Cardiac hypertrophy and remodelling: pathophysiological consequences and protective effects of melatonin.
TL;DR: The results of the publications summarized herein along with numerous other published reports on other aspects of cardiovascular physiology indicate that, when damage to the heart is a result of free radicals, melatonin is clearly protective.
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Melatonin in relation to the "strong" and "weak" versions of the free radical theory of aging.
TL;DR: The data supporting a role for melatonin in forestalling aging and prolonging life span per se is not compelling, but the findings related to melatonin's ability to reduce the severity of a variety of age-related diseases that have as their basis free radical damage is convincing.