R
Rizwan Naeem
Researcher at Baylor College of Medicine
Publications - 20
Citations - 4267
Rizwan Naeem is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Chromosomal translocation & Fluorescence in situ hybridization. The author has an hindex of 12, co-authored 18 publications receiving 4019 citations. Previous affiliations of Rizwan Naeem include Hoffmann-La Roche & Boston Children's Hospital.
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Journal ArticleDOI
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo,Piyush Gupta,Dennis C. Sgroi,Fernando Arenzana-Seisdedos,Thierry Delaunay,Rizwan Naeem,Vincent J. Carey,Andrea L. Richardson,Robert A. Weinberg +8 more
TL;DR: Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients.
Journal ArticleDOI
Cloned transchromosomic calves producing human immunoglobulin
Yoshimi Kuroiwa,Poothappillai Kasinathan,Yoon J. Choi,Rizwan Naeem,Kazuma Tomizuka,Eddie Sullivan,Jason G. Knott,Anae Duteau,Richard A. Goldsby,Barbara A. Osborne,Isao Ishida,James M. Robl +11 more
TL;DR: A human artificial chromosome vector containing the entire unrearranged sequences of the human immunoglobulin heavy-chain (H) and lambda (λ) light-chain loci was introduced into bovine primary fetal fibroblasts using a microcell-mediated chromosome transfer (MMCT) approach.
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Overexpression of Eg5 causes genomic instability and tumor formation in mice.
TL;DR: The results indicate that Eg5 overexpression disrupts the unique balance of forces associated with normal spindle assembly and function, and thereby leads to the development of spindle defects, genetic instability, and tumors.
Journal Article
Overexpression of MAGE/GAGE Genes in Paclitaxel/Doxorubicin-resistant Human Cancer Cell Lines
Zhenfeng Duan,Yifei Duan,Diana E. Lamendola,Rushdia Z. Yusuf,Rizwan Naeem,Richard T. Penson,Michael V. Seiden +6 more
TL;DR: The in vitro acquisition of paclitaxel and doxorubicin resistance can be associated with increased expression of a variety of both neighboring and non-neighboring cancer testis antigens genes, and this does not appear to be a consequence of random genetic instability or genomic amplification of the X chromosome.
Journal ArticleDOI
Syndromic thrombocytopenia and predisposition to acute myelogenous leukemia caused by constitutional microdeletions on chromosome 21q
Marwan Shinawi,Ayelet Erez,Deborah L. Shardy,Brendan Lee,Rizwan Naeem,George Weissenberger,A. Craig Chinault,Sau Wai Cheung,Sharon E. Plon +8 more
TL;DR: It is recommended that children with syndromic thrombocytopenia have clinical array-comparative genomic hybridization analysis and appropriate cytogenetic studies to facilitate the ability to provide a definitive diagnosis.