Edgar Petru

TL;DR: It is found that the plasma DNA read depth patterns from healthy donors reflected the expression signature of hematopoietic cells, and in patients with cancer having metastatic disease, expressed cancer driver genes in regions with somatic copy number gains with high accuracy were classified.

TL;DR: This score is the first prospectively validated instrument to positively predict surgical outcome in recurrent ovarian cancer and will be enrolled in the recently started randomized prospective DESKTOP III trial investigating the role of surgery in recurrent platinum-sensitive ovarian cancer.

TL;DR: L1CAM has been shown to be the best-ever published prognostic factor in FIGO stage I, type I endometrial cancers and shows clear superiority over the standardly used multifactor risk score.

TL;DR: This work determined the plasma DNA size distribution and the fraction of mutated plasma DNA fragments with deep sequencing and an ultrasensitive mutation‐detection method, and described a biphasic distribution in a surprisingly high proportion of cancer patients, which may have important implications for tumor diagnosis and monitoring.

TL;DR: Early tumor stage, age <50 years, and absence of vascular space involvement were independently associated with good prognosis, and Mitotic count failed to act as an independent prognostic parameter in patients with tumor stage II-IV disease.