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Edgardo Moreno
Researcher at University of Costa Rica
Publications - 145
Citations - 9562
Edgardo Moreno is an academic researcher from University of Costa Rica. The author has contributed to research in topics: Brucella & Brucella melitensis. The author has an hindex of 52, co-authored 139 publications receiving 8784 citations. Previous affiliations of Edgardo Moreno include Karolinska Institutet & University of Navarra.
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Journal ArticleDOI
Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum.
Jean Celli,Chantal de Chastellier,Don-Marc Franchini,Javier Pizarro-Cerdá,Edgardo Moreno,Jean-Pierre Gorvel +5 more
TL;DR: It is shown in a model of Brucella abortus infection of murine bone marrow–derived macrophages that a fraction of the bacteria that survive an initial macrophage killing proceed to replicate in a compartment segregated from the endocytic pathway.
Journal ArticleDOI
Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes
Javier Pizarro-Cerdá,Stepahane Meresse,Robert G. Parton,Gisou van der Goot,Alberto Sola-Landa,Ignacio López-Goñi,Edgardo Moreno,Jean-Pierre Gorvel +7 more
TL;DR: The results are compatible with the hypothesis that pathogenic B. abortus exploits the autophagic machinery of HeLa cells to establish an intracellular niche favorable for its replication within the ER.
Journal ArticleDOI
Brucella intracellular life: from invasion to intracellular replication.
TL;DR: The integrity of BrucellA LPS on the bacterial surface is one of the required factors for Brucella intracellular survival, and therefore for virulence.
Journal ArticleDOI
A two‐component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence
Alberto Sola-Landa,Javier Pizarro-Cerdá,María Jesús Grilló,Edgardo Moreno,Ignacio Moriyón,José M. Blasco,Jean-Pierre Gorvel,Ignacio López-Goñi +7 more
TL;DR: Two mutants showing increased sensitivity to polycations and surfactants obtained by transposon mutagenesis of virulent Brucella abortus showed that these systems have a common ancestor that has evolved to sense stimuli in plant and animal microbial environments.
Journal ArticleDOI
Rough vaccines in animal brucellosis: structural and genetic basis and present status.
Ignacio Moriyón,María Jesús Grilló,Daniel Monreal,David González,Clara Marin,Ignacio López-Goñi,Raúl C. Mainar-Jaime,Edgardo Moreno,José M. Blasco +8 more
TL;DR: Rough mutants obtained by molecular biology methods on the knowledge of the genetics and structure of Brucella lipopolysaccharide may offer alternatives, and analyses in mice suggest that mutations affecting only the O-polysaccharides result in better vaccines than those affecting both core and O- polysaccharid.