C
Christopher R. Bolen
Researcher at Genentech
Publications - 63
Citations - 2312
Christopher R. Bolen is an academic researcher from Genentech. The author has contributed to research in topics: Follicular lymphoma & Diffuse large B-cell lymphoma. The author has an hindex of 20, co-authored 55 publications receiving 1586 citations. Previous affiliations of Christopher R. Bolen include University of Colorado Denver & Stanford University.
Papers
More filters
Journal ArticleDOI
Non-equivalence of Wnt and R-spondin ligands during Lgr5 + intestinal stem-cell self-renewal
Kelley S. Yan,Kelley S. Yan,Claudia Y. Janda,Junlei Chang,Grace X.Y. Zheng,Kathryn A. Larkin,Vincent C. Luca,Luis A. Chia,Amanda T. Mah,Arnold Han,Arnold Han,Jessica M. Terry,Akifumi Ootani,Kelly Roelf,Mark Lee,Jenny Yuan,Xiao Li,Christopher R. Bolen,Julie Wilhelmy,Paige S. Davies,Hiroo Ueno,Richard J. von Furstenberg,Phillip Belgrader,Solongo B. Ziraldo,Heather Ordonez,Susan J. Henning,Melissa H. Wong,Michael Snyder,Irving L. Weissman,Aaron J. W. Hsueh,Tarjei S. Mikkelsen,K. Christopher Garcia,Calvin J. Kuo +32 more
TL;DR: This functionally non-equivalent yet cooperative interaction between Wnt and RSPO ligands establishes a molecular precedent for regulation of mammalian stem cells by distinct priming and self-renewal factors, with broad implications for precise control of tissue regeneration.
Journal ArticleDOI
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states
David Furman,David Furman,Junlei Chang,Lydia Lartigue,Christopher R. Bolen,Francois Haddad,Brice Gaudilliere,Edward A. Ganio,Gabriela K. Fragiadakis,Matthew H. Spitzer,Isabelle Douchet,Sophie Daburon,Jean-François Moreau,Garry P. Nolan,Patrick Blanco,Julie Déchanet-Merville,Cornelia L. Dekker,Vladimir Jojic,Calvin J. Kuo,Mark M. Davis,Benjamin Faustin +20 more
TL;DR: It is found that the expression of specific inflammasome gene modules stratifies older individuals into two extremes: those with constitutive expression of IL-1β, nucleotide metabolism dysfunction, elevated oxidative stress, high rates of hypertension and arterial stiffness; and those without constitutive expresses IL- 1β, who lack these characteristics.
Journal ArticleDOI
Quantitative set analysis for gene expression: a method to quantify gene set differential expression including gene-gene correlations
TL;DR: QuSAGE accounts for inter-gene correlations, improves the estimation of the variance inflation factor, and quantifies gene-set activity with a complete probability density function, which exhibits better sensitivity and specificity on real data profiling the response to interferon therapy and Influenza A virus infection.
Journal ArticleDOI
Dynamic expression profiling of type I and type III interferon-stimulated hepatocytes reveals a stable hierarchy of gene expression
TL;DR: The quantitative expression hierarchy and unique kinetics of IFN‐α reveal potential specific roles for individual IFNs in the immune response, and elucidate the mechanism behind previously observed differences in IFN antiviral activity.
Journal ArticleDOI
Venetoclax Plus Rituximab in Relapsed Chronic Lymphocytic Leukemia: 4-Year Results and Evaluation of Impact of Genomic Complexity and Gene Mutations From the MURANO Phase III Study
Arnon P. Kater,Jenny Wu,Thomas J. Kipps,Barbara Eichhorst,Peter Hillmen,James D'Rozario,Sarit Assouline,Carolyn Owen,Tadeusz Robak,Javier de la Serna,Ulrich Jaeger,Guillaume Cartron,Marco Montillo,Julie Dubois,Eric Eldering,Clemens Mellink,Anne-Marie van der Kevie-Kersemaekers,Su Young Kim,Brenda Chyla,Elizabeth Punnoose,Christopher R. Bolen,Zoe June Assaf,Yanwen Jiang,Jue Wang,Marcus Lefebure,Michelle Boyer,Kathryn Humphrey,John F. Seymour +27 more
TL;DR: Efficacy benefits with fixed-duration VenR are sustained and particularly durable in patients who achieve uMRD, and Salvage therapy with ibrutinib after VenR achieved high response rates.