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Gabriela K. Fragiadakis
Researcher at University of California, San Francisco
Publications - 61
Citations - 2895
Gabriela K. Fragiadakis is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 17, co-authored 47 publications receiving 1434 citations. Previous affiliations of Gabriela K. Fragiadakis include Stanford University & University of California, Berkeley.
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Journal ArticleDOI
Gut-microbiota-targeted diets modulate human immune status.
Hannah C Wastyk,Gabriela K. Fragiadakis,Dalia Perelman,Dylan Dahan,Bryan D. Merrill,Feiqiao Brian Yu,Madeline Topf,Carlos Gonzalez,Will Van Treuren,Shuo Han,Jennifer L. Robinson,Joshua E. Elias,Erica D. Sonnenburg,Christopher D. Gardner,Justin L. Sonnenburg +14 more
TL;DR: In this paper, a 17-week randomized, prospective study (n = 18/arm) combined with -omics measurements of microbiome and host, including extensive immune profiling, was conducted to determine how two microbiota-targeted dietary interventions, plant-based fiber and fermented foods, influence the human microbiome and immune system in healthy adults.
Journal ArticleDOI
Clinical recovery from surgery correlates with single-cell immune signatures.
Brice Gaudilliere,Gabriela K. Fragiadakis,Robert V. Bruggner,Monica Nicolau,Rachel Finck,Martha Tingle,Julian Silva,Edward A. Ganio,Christine G. Yeh,William J. Maloney,James I. Huddleston,Stuart B. Goodman,Mark M. Davis,Sean C. Bendall,Wendy J. Fantl,Martin S. Angst,Garry P. Nolan +16 more
TL;DR: The capacity of mass cytometry to survey the human immune system in a relevant clinical context is demonstrated and mechanistically derived immune correlates point to diagnostic signatures, and potential therapeutic targets, that could postoperatively improve patient recovery.
Journal ArticleDOI
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states
David Furman,David Furman,Junlei Chang,Lydia Lartigue,Christopher R. Bolen,Francois Haddad,Brice Gaudilliere,Edward A. Ganio,Gabriela K. Fragiadakis,Matthew H. Spitzer,Isabelle Douchet,Sophie Daburon,Jean-François Moreau,Garry P. Nolan,Patrick Blanco,Julie Déchanet-Merville,Cornelia L. Dekker,Vladimir Jojic,Calvin J. Kuo,Mark M. Davis,Benjamin Faustin +20 more
TL;DR: It is found that the expression of specific inflammasome gene modules stratifies older individuals into two extremes: those with constitutive expression of IL-1β, nucleotide metabolism dysfunction, elevated oxidative stress, high rates of hypertension and arterial stiffness; and those without constitutive expresses IL- 1β, who lack these characteristics.
Posted ContentDOI
Gut Microbiota-Targeted Diets Modulate Human Immune Status
Hannah C Wastyk,Gabriela K. Fragiadakis,Dalia Perelman,Dylan Dahan,Bryan D. Merrill,Feiqiao Brian Yu,Madeline Topf,Carlos Gonzalez,Jennifer L. Robinson,Joshua E. Elias,Erica D. Sonnenburg,Christopher D. Gardner,Justin L. Sonnenburg +12 more
TL;DR: This article used a 17-week randomized, prospective study design combined with -omics measurements of microbiome and host, including extensive immune profiling, to determine how each diet affects the human microbiome and immune system in healthy adults.
Journal ArticleDOI
An Interactive Reference Framework for Modeling a Dynamic Immune System
Matthew H. Spitzer,Pier Federico Gherardini,Gabriela K. Fragiadakis,Nupur Bhattacharya,Robert Yuan,Andrew Hotson,Rachel Finck,Yaron Carmi,Eli R. Zunder,Wendy J. Fantl,Sean C. Bendall,Edgar G. Engleman,Garry P. Nolan +12 more
TL;DR: This foundational reference map provides a working definition of systemic immune organization to which new data can be integrated to reveal deviations driven by genetics, environment, or pathology.