E
Eileen White
Researcher at Rutgers University
Publications - 241
Citations - 51179
Eileen White is an academic researcher from Rutgers University. The author has contributed to research in topics: Autophagy & Programmed cell death. The author has an hindex of 95, co-authored 226 publications receiving 44992 citations. Previous affiliations of Eileen White include University of Tokyo & University of Medicine and Dentistry of New Jersey.
Papers
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Journal ArticleDOI
Inhibition of ICE-like proteases inhibits apoptosis and increases virus production during adenovirus infection.
Shiun-Kwei Chiou,Eileen White +1 more
TL;DR: Inhibition of apoptosis by Z-VAD-FMK significantly enhanced production of infectious adenovirus and attenuated virus release, suggesting that apoptosis may be a method for the host cell to limit virus production and release at the end of the infection cycle.
Journal ArticleDOI
Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response
Laura Poillet-Perez,Daniel W. Sharp,Yang Yang,Saurabh V. Laddha,Maria Ibrahim,Praveen K. Bommareddy,Zhixian Sherrie Hu,Joshua A. Vieth,Michael Haas,Marcus Bosenberg,Joshua D. Rabinowitz,Joshua D. Rabinowitz,Jian Cao,Jun-Lin Guan,Shridar Ganesan,Chang S. Chan,Janice M. Mehnert,Edmund C. Lattime,Eileen White +18 more
TL;DR: It is shown that autophagy, especially in the liver, promotes tumor immune tolerance by enabling regulatory T-cell function and limiting stimulator of interferon genes, T- cell response and interferons-γ, which enables growth of high-TMB tumors.
Journal ArticleDOI
Bcl-2 modulation to activate apoptosis in prostate cancer.
Kevin Bray,Hsin-Yi Chen,Cristina M. Karp,Michael May,Shridar Ganesan,Vassiliki Karantza-Wadsworth,Robert S. DiPaola,Eileen White +7 more
TL;DR: In human prostate cancer tissue examined using a novel tumor explant system designated Tumor Tissue Assessment for Response to Chemotherapy, combination chemotherapy promoted efficient apoptosis and rational targeting of both the Bcl-2 and Mcl-1 mechanisms of apoptosis resistance may be therapeutically advantageous for advanced prostate cancer.
Book ChapterDOI
Therapeutic targeting of death pathways in cancer: mechanisms for activating cell death in cancer cells.
Ting-Ting Tan,Eileen White +1 more
TL;DR: This chapter summarizes the current knowledge of the apoptosis pathways and provides a selective review on the development of drugs that target the apoptotic machinery.
Journal ArticleDOI
Autophagy Regulates Keratin 8 Homeostasis in Mammary Epithelial Cells and in Breast Tumors
Sameera Kongara,Olga Kravchuk,Irina Teplova,Fred Lozy,Jennifer Schulte,Dirk F. Moore,Nicola Barnard,Carola A. Neumann,Eileen White,Vassiliki Karantza +9 more
TL;DR: It is reported that autophagy deficiency is associated with endoplasmic reticulum (ER) and oxidative stress, and with deregulation of p62-mediated keratin homeostasis in mammary cells, allograft tumors, and mammary tissues from genetically engineered mice.