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Eileen White
Researcher at Rutgers University
Publications - 241
Citations - 51179
Eileen White is an academic researcher from Rutgers University. The author has contributed to research in topics: Autophagy & Programmed cell death. The author has an hindex of 95, co-authored 226 publications receiving 44992 citations. Previous affiliations of Eileen White include University of Tokyo & University of Medicine and Dentistry of New Jersey.
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Journal ArticleDOI
Serine Catabolism Feeds NADH when Respiration Is Impaired.
Lifeng Yang,Juan Carlos Garcia Canaveras,Zihong Chen,Lin Wang,Lingfan Liang,Cholsoon Jang,Johannes A. Mayr,Zhaoyue Zhang,Jonathan M. Ghergurovich,Le Zhan,Shilpy Joshi,Zhixian Hu,Melanie R. McReynolds,Xiaoyang Su,Eileen White,Raphael J. Morscher,Joshua D. Rabinowitz +16 more
TL;DR: Deuterium-tracing studies in cultured cells and mice show that folate-dependent serine catabolism also produces substantial NADH, and when respiration is impaired, serineCatabolism contributes to toxic NADH accumulation.
Journal ArticleDOI
Autophagy, Stress, and Cancer Metabolism: What Doesn't Kill You Makes You Stronger
Robin Mathew,Eileen White +1 more
TL;DR: Targeting autophagy in single-agent therapy to sensitize aggressive cancers that are dependent on autophagic for survival or in combination with therapeutic agents that induce autophile as a resistance mechanism may be an effective therapeutic strategy to treat cancer.
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Role of the Polarity Determinant Crumbs in Suppressing Mammalian Epithelial Tumor Progression
Cristina M. Karp,Ting Ting Tan,Robin Mathew,Deidre Nelson,Chandreyee Mukherjee,Kurt Degenhardt,Vassiliki Karantza-Wadsworth,Eileen White +7 more
TL;DR: A role for mammalian polarity determinants in suppressing tumorigenesis that may be analogous to the well-studied polarity tumor suppressor mechanisms in Drosophila is suggested.
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Autophagy is required for mitochondrial function, lipid metabolism, growth, and fate of KRAS(G12D)-driven lung tumors.
Jessie Yanxiang Guo,Eileen White +1 more
TL;DR: It is found that deletion of the essential autophagy gene, Atg7, in KRASG12D-driven NSCLC inhibits tumor growth and converts adenomas and adenocarcinomas to benign oncocytomas characterized by the accumulation of respiration-defective mitochondria.
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Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy.
Robert S. DiPaola,Dmitri Dvorzhinski,Anu Thalasila,V. P. S. Garikapaty,Donyell Doram,Michael May,Kevin Bray,Robin Mathew,Brian Beaudoin,Cristina M. Karp,M. N. Stein,David J. Foran,Eileen White +12 more
TL;DR: The understanding of autophagy, as either a mechanism of resistance to therapies that induce metabolic stress, or as a means to cell death, is rapidly expanding and supportive of a new paradigm of therapeutic starvation.