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Eileen White
Researcher at Rutgers University
Publications - 241
Citations - 51179
Eileen White is an academic researcher from Rutgers University. The author has contributed to research in topics: Autophagy & Programmed cell death. The author has an hindex of 95, co-authored 226 publications receiving 44992 citations. Previous affiliations of Eileen White include University of Tokyo & University of Medicine and Dentistry of New Jersey.
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Journal ArticleDOI
Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria
Sudha Singh,Wojciech Ornatowski,Isabelle Vergne,John Naylor,Mónica A. Delgado,Esteban A. Roberts,Marisa Ponpuak,Marisa Ponpuak,Sharon Master,Manohar Pilli,Eileen White,Masaaki Komatsu,Masaaki Komatsu,Vojo Deretic +13 more
TL;DR: By acting on mitochondria, IRGM confers autophagic protection or cell death, explaining IRGM action both in defence against tuberculosis and in the damaging inflammation caused by Crohn's disease.
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Four Key Steps Control Glycolytic Flux in Mammalian Cells.
Lukas B. Tanner,Alexander G. Goglia,Monica H. Wei,Talen Sehgal,Lance Parsons,Junyoung O. Park,Eileen White,Jared E. Toettcher,Joshua D. Rabinowitz +8 more
TL;DR: Flux control in glycolysis is concentrated in four key enzymatic steps, specifically upregulated by the Ras oncogene: optogenetic Ras activation rapidly induces the transcription of isozymes catalyzing these four steps and enhances gly colysis.
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Autophagy and p53
TL;DR: Uncovering the underlying mechanisms of the autophagy-p53 reciprocal functional interaction and has important implications for human disease and treatment.
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Autophagy maintains tumour growth through circulating arginine
Laura Poillet-Perez,Xiaoqi Xie,Le Zhan,Yang Yang,Daniel W. Sharp,Zhixian Sherrie Hu,Xiaoyang Su,Anurag Maganti,Cherry Jiang,Wenyun Lu,Haiyan Zheng,Marcus Bosenberg,Janice M. Mehnert,Jessie Yanxiang Guo,Edmund C. Lattime,Joshua D. Rabinowitz,Joshua D. Rabinowitz,Eileen White +17 more
TL;DR: It is shown that host-specific deletion of Atg7 impairs the growth of multiple allografted tumours, although not all tumour lines were sensitive to host autophagy status, and this identifies a metabolic vulnerability of cancer.
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Metabolic catastrophe as a means to cancer cell death.
TL;DR: Tumor cells cannot adapt efficiently to metabolic stress and could be induced to die by metabolic catastrophe, in which high energy demand is contrasted by insufficient energy production.