E
Eirini P. Papapetrou
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 76
Citations - 8160
Eirini P. Papapetrou is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Induced pluripotent stem cell & Reprogramming. The author has an hindex of 25, co-authored 64 publications receiving 7010 citations. Previous affiliations of Eirini P. Papapetrou include University of Patras & Kettering University.
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Gene transfer into human hematopoietic progenitor cells with an episomal vector carrying an S/MAR element.
TL;DR: The results provide the first evidence that S/MAR-based plasmids can function as stable episomes in primary human cells, supporting long-term transgene expression, and do not display universal behavior in all cell types.
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A genetic strategy for single and combinatorial analysis of miRNA function in mammalian hematopoietic stem cells.
TL;DR: A role is revealed for the miR‐144/451 locus in mammalian erythropoiesis and the first evidence of functional cooperativity between clustered miRNAs in the hematopoietic system is provided, and a strategy for stable in vivo individual and combinatorial miRNA inhibition is developed.
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Generation of transgene-free human induced pluripotent stem cells with an excisable single polycistronic vector
TL;DR: This protocol can be used to efficiently derive transgene-free iPSCs from many different starting cell types in approximately 12–14 weeks and maintain all characteristics of pluripotency.
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A method to sequence and quantify DNA integration for monitoring outcome in gene therapy
Troy Brady,Shoshannah L. Roth,Nirav Malani,Gary P. Wang,Charles C. Berry,Philippe Leboulch,Salima Hacein-Bey-Abina,Marina Cavazzana-Calvo,Eirini P. Papapetrou,Michel Sadelain,Harri Savilahti,Frederic D. Bushman +11 more
TL;DR: It is shown that a new method based on phage Mu transposition in vitro allows convenient and consistent recovery of integration site sequences in a form that can be analyzed directly using DNA barcoding and pyrosequencing.
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Transcriptional Activation by Oct4 Is Sufficient for the Maintenance and Induction of Pluripotency
Fella Hammachi,Gillian Morrison,Alexei A. Sharov,Alessandra Livigni,Santosh Narayan,Eirini P. Papapetrou,James O’Malley,Keisuke Kaji,Minoru S.H. Ko,Mark Ptashne,Joshua M. Brickman,Joshua M. Brickman +11 more
TL;DR: It is concluded that the necessary and sufficient function of Oct4 in promoting pluripotency is to activate specific target genes.