E
Eirini P. Papapetrou
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 76
Citations - 8160
Eirini P. Papapetrou is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Induced pluripotent stem cell & Reprogramming. The author has an hindex of 25, co-authored 64 publications receiving 7010 citations. Previous affiliations of Eirini P. Papapetrou include University of Patras & Kettering University.
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Genetic modification of hematopoietic stem cells with nonviral systems : past progress and future prospects
TL;DR: It is argued that episomally maintained self-replicating vectors combined with physical methods of delivery show the greatest promise among nonviral gene transfer strategies for the treatment of disorders of the hematopoietic system.
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Harnessing endogenous miR-181a to segregate transgenic antigen receptor expression in developing versus post-thymic T cells in murine hematopoietic chimeras
TL;DR: The results demonstrate the potential of miRNA-regulated transgene expression in stem cell-based therapies, including cancer immunotherapy, as well as the need for further research into this area.
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Efficient genome editing in hematopoietic stem cells with helper-dependent Ad5/35 vectors expressing site-specific endonucleases under microRNA regulation.
Kamola Saydaminova,Xun Ye,Hongjie Wang,Maximilian Richter,Martin Ho,HongZhuan Chen,Ning Xu,Jin-Soo Kim,Eirini P. Papapetrou,Michael C. Holmes,Philip D. Gregory,Donna Palmer,Philip Ng,Anja Ehrhardt,André Lieber +14 more
TL;DR: The miRNA regulated HD-Ad5/35 vector platform for expression of site-specific endonucleases has numerous advantages over currently used vectors as a tool for genome engineering of HSCs for therapeutic purposes.
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SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications
Shalini Singh,Doaa Ahmed,Doaa Ahmed,Hamid Dolatshad,Dharamveer Tatwavedi,Ulrike Schulze,Andrea Sanchi,Sarah Ryley,Ashish Dhir,Lee Carpenter,Suzanne M. Watt,David J. Roberts,Amal M. Abdel-Aal,Sohair K. Sayed,Somaia A. Mohamed,Anna Schuh,Paresh Vyas,Sally Killick,Andriana G. Kotini,Eirini P. Papapetrou,Daniel H. Wiseman,Andrea Pellagatti,Jacqueline Boultwood +22 more
TL;DR: Pellagatti et al. as discussed by the authors found that splicing factor mutations affect transcription and may lead to the accumulation of Rloops (RNA-DNA hybrids with a displaced single stranded DNA) and increased DNA damage, replication stress, and activation of the ATR-Chk1 pathway.
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Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCs
Chan Jung Chang,Andriana G. Kotini,Malgorzata Olszewska,Maria Georgomanoli,Julie Teruya-Feldstein,Henrik Sperber,Roberto Sanchez,Robert J. DeVita,Timothy J. Martins,Omar Abdel-Wahab,Robert K. Bradley,Eirini P. Papapetrou +11 more
TL;DR: In this article, the authors used patient-derived induced pluripotent stem cells (iPSCs) and CRISPR/Cas9 genome editing to dissect the individual contributions of two recurrent genetic lesions, the splicing factor SRSF2 P95L mutation and the chromosome 7q deletion, to the development of myeloid malignancy.