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Ekrem Darendelioglu
Researcher at Bingöl University
Publications - 23
Citations - 587
Ekrem Darendelioglu is an academic researcher from Bingöl University. The author has contributed to research in topics: Oxidative stress & Apoptosis. The author has an hindex of 8, co-authored 15 publications receiving 277 citations. Previous affiliations of Ekrem Darendelioglu include University of Leicester.
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Journal ArticleDOI
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.
Hugo Vicente Miranda,Hugo Vicente Miranda,Éva M. Szegö,Luís M. A. Oliveira,Luís M. A. Oliveira,Carlo Breda,Ekrem Darendelioglu,Ekrem Darendelioglu,Rita Machado de Oliveira,Rita Machado de Oliveira,Diana G. Ferreira,Diana G. Ferreira,Marcos António Gomes,Ruth Rott,Márcia Oliveira,Francesca Munari,Francesca Munari,Francisco J. Enguita,Tania Simões,Eva F. Rodrigues,Michael Heinrich,Ivo C. Martins,Irina Zamolo,Olaf Riess,Carlos Cordeiro,Ana Ponces-Freire,Hilal A. Lashuel,Nuno C. Santos,Luísa V. Lopes,Wei Xiang,Thomas M. Jovin,Deborah Penque,Simone Engelender,Markus Zweckstetter,Markus Zweckstetter,Markus Zweckstetter,Jochen Klucken,Flaviano Giorgini,Alexandre Quintas,Tiago F. Outeiro +39 more
TL;DR: Glycation constitutes a novel drug target that can be explored in synucleinopathies as well as in other neurodegenerative conditions and is demonstrated that normal clearance of α-synuclein was re-established, aggregation was reduced, and motor phenotypes in Drosophila were alleviated.
Journal ArticleDOI
Protective effects of morin against acrylamide-induced hepatotoxicity and nephrotoxicity: A multi-biomarker approach.
Fatih Mehmet Kandemir,Serkan Yildirim,Sefa Kucukler,Cuneyt Caglayan,Ekrem Darendelioglu,Muhammet Bahaeddin Dortbudak +5 more
TL;DR: Morin treatment attenuated the ACR-induced hepatorenal tissue injury by diminishing the serum AST, ALP, ALT, urea and creatinine levels and affected the protein levels by regulating the PI3K/Akt/mTOR signaling pathway and thus alleviated ACr-induced apoptosis and autophagy.
Journal ArticleDOI
Rutin ameliorates mercuric chloride-induced hepatotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis.
Cuneyt Caglayan,Fatih Mehmet Kandemir,Ekrem Darendelioglu,Serkan Yildirim,Sefa Kucukler,Muhammet Bahaeddin Dortbudak +5 more
TL;DR: It is suggested that rutin effectively suppress HgCl2-induced hepatotoxicity by ameliorating oxidative stress, inflammation and apoptosis.
Journal ArticleDOI
Morin attenuates acrylamide-induced testicular toxicity in rats by regulating the NF-κB, Bax/Bcl-2 and PI3K/Akt/mTOR signaling pathways.
TL;DR: Treatment with morin could significantly decrease MDA level and considerably increase the activity of antioxidant enzymes and GSH level in the testicular tissue of the AC-treated rats, showing the possible protective mechanism of morin, a potential therapeutic agent for AC-induced testicular toxicity.
Journal ArticleDOI
Zingerone attenuates vancomycin-induced hepatotoxicity in rats through regulation of oxidative stress, inflammation and apoptosis
Sefa Kucukler,Ekrem Darendelioglu,Cuneyt Caglayan,Adnan Ayna,Serkan Yildirim,Fatih Mehmet Kandemir +5 more
TL;DR: Zin treatment significantly improved VCM-induced hepatic lipid peroxidation, glutathione depletion, reduced antioxidant enzyme activities and liver function markers and probable ameliorative role of Zin is revealed against V CM-induced hepatotoxicity.