F
Francisco J. Enguita
Researcher at Instituto de Medicina Molecular
Publications - 133
Citations - 3406
Francisco J. Enguita is an academic researcher from Instituto de Medicina Molecular. The author has contributed to research in topics: microRNA & Gene. The author has an hindex of 26, co-authored 121 publications receiving 2615 citations. Previous affiliations of Francisco J. Enguita include Universidade Nova de Lisboa & University of León.
Papers
More filters
Journal ArticleDOI
Crystal structure of a bacterial endospore coat component. A laccase with enhanced thermostability properties.
Francisco J. Enguita,Lígia O. Martins,Lígia O. Martins,Adriano O. Henriques,Maria Arménia Carrondo +4 more
TL;DR: Comparisons with the structure of other monomeric multicopper oxidases containing four copper atoms suggest that CotA may accept the largest substrates of any known laccase, and unlike other laccases, CotA appears to have a flexible lidlike region close to the substrate-binding site that may mediate substrate accessibility.
Journal ArticleDOI
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
Rita Machado de Oliveira,Hugo Vicente Miranda,Laetitia Francelle,Raquel Pinho,Raquel Pinho,Éva M. Szegö,Renato Martinho,Francesca Munari,Francesca Munari,Diana F. Lázaro,Sébastien Moniot,Patrícia Guerreiro,Luis Fonseca-Ornelas,Zrinka Marijanovic,Pedro Antas,Ellen Gerhardt,Francisco J. Enguita,Bruno Fauvet,Deborah Penque,Teresa F. Pais,Qiang Tong,Stefan Becker,Sebastian Kügler,Hilal A. Lashuel,Clemens Steegborn,Markus Zweckstetter,Markus Zweckstetter,Markus Zweckstetter,Tiago F. Outeiro +28 more
TL;DR: It is found that α-synuclein is acetylated on lysines 6 and 10 and that these residues are deacetylated by sirtuin 2, demonstrating the potential therapeutic value of sIRTuin 2 inhibition in synucleinopathies.
Journal ArticleDOI
Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis.
Teresa Ribeiro-Rodrigues,Tiago L. Laundos,Rita Pereira-Carvalho,Daniela Batista-Almeida,Ricardo Pereira,Vanessa Coelho-Santos,Ana P. Silva,Rosa Fernandes,Mónica Zuzarte,Francisco J. Enguita,Marina C. Costa,Perpétua Pinto-do-Ó,Marta Pinto,Pedro Gouveia,Lino Ferreira,Justin C Mason,Paulo Pereira,Paulo Pereira,Brenda R. Kwak,Diana S. Nascimento,Henrique Girão +20 more
TL;DR: It is established that exosomes secreted by cardiomyocytes under ischaemic conditions promote heart angiogenesis, which may pave the way towards the development of add-on therapies to enhance myocardial blood supply.
Journal ArticleDOI
Substrate and dioxygen binding to the endospore coat laccase from Bacillus subtilis.
Francisco J. Enguita,David Marçal,Lígia O. Martins,Lígia O. Martins,Rosa Grenha,Adriano O. Henriques,Peter F. Lindley,Maria Arménia Carrondo +7 more
TL;DR: In this article, the Bacillus subtilis endospore coat was crystallized in the presence of the non-catalytic co-oxidant 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS), and the structure was determined using synchrotron radiation.
Journal ArticleDOI
Hydroquinone: Environmental Pollution, Toxicity, and Microbial Answers
TL;DR: This review underscores not only the mechanisms of hydroquinone biotransformation and the role of microorganisms and their enzymes in this process, but also its toxicity.