Journal ArticleDOI
Protective effects of morin against acrylamide-induced hepatotoxicity and nephrotoxicity: A multi-biomarker approach.
Fatih Mehmet Kandemir,Serkan Yildirim,Sefa Kucukler,Cuneyt Caglayan,Ekrem Darendelioglu,Muhammet Bahaeddin Dortbudak +5 more
TLDR
Morin treatment attenuated the ACR-induced hepatorenal tissue injury by diminishing the serum AST, ALP, ALT, urea and creatinine levels and affected the protein levels by regulating the PI3K/Akt/mTOR signaling pathway and thus alleviated ACr-induced apoptosis and autophagy.About:
This article is published in Food and Chemical Toxicology.The article was published on 2020-02-14. It has received 91 citations till now. The article focuses on the topics: Morin & Nephrotoxicity.read more
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Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-κB, ATF-6 pathways and activating Nrf2, Akt pathways.
Ahmet Yardim,Fatih Mehmet Kandemir,Selçuk Özdemir,Sefa Kucukler,Selim Çomaklı,Cihan Gur,Hamit Çelik +6 more
TL;DR: Quercetin was determined to relieve oxidative stress, oxidative DNA damage, neuronal cell damage, inflammation, ER stress, and apoptosis caused by vincristine and enable Akt activation.
Journal ArticleDOI
Lycopene protects against central and peripheral neuropathy by inhibiting oxaliplatin-induced ATF-6 pathway, apoptosis, inflammation and oxidative stress in brains and sciatic tissues of rats
Hamit Çelik,Sefa Kucukler,Selçuk Özdemir,Selim Çomaklı,Cihan Gur,Fatih Mehmet Kandemir,Ahmet Yardim +6 more
TL;DR: Lycopene can be beneficial in ameliorating OXL-induced central and peripheral nerve injuries by showing antioxidant, anti-inflammatory and anti-apoptotic properties in the brain and sciatic tissue.
Journal ArticleDOI
Silymarin alleviates docetaxel-induced central and peripheral neurotoxicity by reducing oxidative stress, inflammation and apoptosis in rats.
Ahmet Yardim,Sefa Kucukler,Selçuk Özdemir,Selim Çomaklı,Cuneyt Caglayan,Fatih Mehmet Kandemir,Hamit Çelik +6 more
TL;DR: The results show that silymarin can protect DTX-induced brain and sciatic nerve injuries by enhancing the antioxidant defense system and suppressing apoptosis and inflammation.
Journal ArticleDOI
Morin attenuates acrylamide-induced testicular toxicity in rats by regulating the NF-κB, Bax/Bcl-2 and PI3K/Akt/mTOR signaling pathways.
TL;DR: Treatment with morin could significantly decrease MDA level and considerably increase the activity of antioxidant enzymes and GSH level in the testicular tissue of the AC-treated rats, showing the possible protective mechanism of morin, a potential therapeutic agent for AC-induced testicular toxicity.
Journal ArticleDOI
Morin hydrate: A comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential.
TL;DR: Morin hydrate is a bio-flavonoid mainly obtained from fruits, stem, and leaves of Moraceae family members' plants as discussed by the authors, which exhibits its pharmacological activities by modulating various cellular signaling pathways such as Nuclear factor kappa-light-chainenhancer of activated B cells (NF-қB), Mitogen-activated protein kinase (MAPK), Janus kinases/ Signal transducer and activator of transcription proteins (JAKs/STATs), Kelch-like ECH-associated protein1/Nuclear eryth
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent
Jozef Sedlak,Raymond H. Lindsay +1 more
TL;DR: A simple spectrophotometric method for the routine concomitant determination of sulfhydryl groups in PB- SH, NP-SH, and T-SH fractions in various tissues is reported.
Journal ArticleDOI
A simple method for clinical assay of superoxide dismutase.
Yi Sun,L. W. Oberley,Ying Li +2 more
TL;DR: The Cu,ZnSOD concentrations in serum and plasma of patients with cancer of the large intestine tended to be less and greater than these values, respectively, but not statistically significantly so.
Journal ArticleDOI
Glutathione peroxidase activity in selenium-deficient rat liver☆
TL;DR: Two peaks of glutathione peroxidase activity were present in the Sephadex G-150 gel filtration chromatogram of rat liver supernatant when 1.5 mM cumene hydroperoxide was used as substrate, and the second peak represents a second glutathienase activity which catalyzes the destruction of organic hydroperoxides but has little activity toward H 2 O 2 and which persists in severe selenium deficiency.
Journal ArticleDOI
Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems.
TL;DR: Alkaline pyridine-butanol mixture dissolves both proteins and lipids that are precipitated or opalescent during the reaction, yielding a more accurate MDA estimation as well as simplifying the procedure.
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Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent
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