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Ela Smiljanic-Hurley
Researcher at Medical Research Council Technology
Publications - 9
Citations - 268
Ela Smiljanic-Hurley is an academic researcher from Medical Research Council Technology. The author has contributed to research in topics: Plasmodium falciparum & cGMP-dependent protein kinase. The author has an hindex of 7, co-authored 9 publications receiving 206 citations.
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Journal ArticleDOI
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.
David A. Baker,Lindsay B. Stewart,Jonathan M. Large,Paul W. Bowyer,Keith H. Ansell,María Belén Jiménez-Díaz,Majida El Bakkouri,Majida El Bakkouri,Kristian Birchall,Koen J. Dechering,Nathalie Bouloc,P.J. Coombs,David Whalley,Denise J. Harding,Ela Smiljanic-Hurley,Mary C. Wheldon,Eloise M. Walker,Johannes T. Dessens,Maria Lafuente,Laura Sanz,Francisco-Javier Gamo,Santiago Ferrer,Raymond Hui,Raymond Hui,Teun Bousema,Iñigo Angulo-Barturen,Andy Merritt,Simon L. Croft,Winston E. Gutteridge,Catherine A. Kettleborough,Simon A. Osborne +30 more
TL;DR: An imidazopyridine series is generated that selectively targets Plasmodium falciparum PKG, inhibits blood stage parasite growth in vitro and in mice and blocks transmission to mosquitoes and warrants consideration for further development to produce an antimalarial drug.
Journal ArticleDOI
Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.
Edward G. McIver,Justin S. Bryans,Kristian Birchall,Jasveen Chugh,Tom Drake,Stephen John Lewis,Joanne Osborne,Ela Smiljanic-Hurley,William Tsang,Ahmad Kamal,Alison Levy,Michelle Newman,Debra L. Taylor,J. Simon C. Arthur,Kristopher Clark,Philip Cohen +15 more
TL;DR: Starting from BX795, originally reported to be a potent inhibitor of PDK1, compounds with improved selectivity and drug-like properties are developed, enabling us to probe the putative role of the TBK1/IKKε pathway in inflammatory diseases.
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Biochemical and Antiparasitic Properties of Inhibitors of the Plasmodium falciparum Calcium-Dependent Protein Kinase PfCDPK1
Keith H. Ansell,Hayley M. Jones,David Whalley,Alisdair Hearn,Debra L. Taylor,Emmanuel C. Patin,Timothy M. Chapman,Simon A. Osborne,Claire Wallace,Kristian Birchall,Jonathan M. Large,Nathalie Bouloc,Ela Smiljanic-Hurley,Barbara Clough,Robert W. Moon,Judith L. Green,Anthony A. Holder +16 more
TL;DR: Potent inhibition was combined with acceptable absorption, distribution, metabolism, excretion, and toxicity properties and equipotent inhibition of Plasmodium vivax CDPK1, however, it was unable to correlate biochemical inhibition with parasite growth inhibition for this series overall.
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Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues.
Jonathan M. Large,Simon A. Osborne,Ela Smiljanic-Hurley,Keith H. Ansell,Hayley M. Jones,Debra L. Taylor,Barbara Clough,Judith L. Green,Anthony A. Holder +8 more
TL;DR: The structural diversity and SAR in a series of imidazopyridazine inhibitors of Plasmodium falciparum calcium dependent protein kinase 1 (PfCDPK1) has been explored and extended as discussed by the authors.
Journal ArticleDOI
Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).
Denise J. Tsagris,Kristian Birchall,Nathalie Bouloc,Jonathan M. Large,Andy Merritt,Ela Smiljanic-Hurley,Mary C. Wheldon,Keith H. Ansell,Catherine A. Kettleborough,David Whalley,Lindsay B. Stewart,Paul W. Bowyer,David A. Baker,Simon A. Osborne +13 more
TL;DR: A series of trisubstituted thiazoles have been identified as potent inhibitors of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) through template hopping from known Eimeria PKG (Et PKG) inhibitors.