R
Robert W. Moon
Researcher at University of London
Publications - 56
Citations - 1760
Robert W. Moon is an academic researcher from University of London. The author has contributed to research in topics: Plasmodium knowlesi & Plasmodium falciparum. The author has an hindex of 19, co-authored 46 publications receiving 1324 citations. Previous affiliations of Robert W. Moon include National Institute for Medical Research & Wellcome Trust Sanger Institute.
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Journal ArticleDOI
Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes
Robert W. Moon,Joanna Hall,Farania Rangkuti,YungShwen Ho,Neil Almond,Graham H. Mitchell,Arnab Pain,Anthony A. Holder,Michael J. Blackman +8 more
TL;DR: Human-adapted P. knowlesi clones maintain their capacity to replicate in monkey erythrocytes and can be genetically modified with unprecedented efficiency, providing an important and unique model for studying conserved aspects of malarial biology as well as species-specific features of an emerging pathogen.
Journal ArticleDOI
A cyclic GMP signalling module that regulates gliding motility in a malaria parasite.
Robert W. Moon,Cathy J. Taylor,Claudia Bex,Rebecca Schepers,David Goulding,Chris J. Janse,Andrew P. Waters,David A. Baker,Oliver Billker,Oliver Billker +9 more
TL;DR: Data demonstrate an important function for signalling through cGMP, and most likely PKG, in dynamically regulating ookinete gliding during the transmission of malaria to the mosquito.
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Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion
Mahmood M. Alam,Lev Solyakov,Andrew R. Bottrill,Christian Flueck,Faiza Amber Siddiqui,Shailja Singh,Sharad Mistry,Maria Viskaduraki,Kate D. Lee,Christine S. Hopp,Chetan E. Chitnis,Christian Doerig,Robert W. Moon,Judith L. Green,Anthony A. Holder,David A. Baker,Andrew B. Tobin +16 more
TL;DR: The phosphorylation sites on 69 proteins involved in cell signalling, proteolysis, gene regulation, protein export and ion and protein transport are identified, indicating that cGMP/PfPKG acts as a signalling hub that plays a central role in a number of core parasite processes.
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An atypical mitogen-activated protein kinase controls cytokinesis and flagellar motility during male gamete formation in a malaria parasite
TL;DR: Data demonstrate a function for Pbmap‐2 in initiating cytokinesis and axoneme motility, possibly downstream of a cell cycle checkpoint for the completion of replication and/or mitosis, which are extraordinarily rapid in the male gametocyte.
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Comparative Heterochromatin Profiling Reveals Conserved and Unique Epigenome Signatures Linked to Adaptation and Development of Malaria Parasites.
Sabine Anne-Kristin Fraschka,Michael Filarsky,Michael Filarsky,Regina Hoo,Igor Niederwieser,Igor Niederwieser,Xue Yan Yam,Nicolas M. B. Brancucci,Nicolas M. B. Brancucci,Franziska Mohring,Annals Tatenda Mushunje,Ximei Huang,Peter R. Christensen,François Nosten,François Nosten,Zbynek Bozdech,Bruce Russell,Robert W. Moon,Matthias Marti,Matthias Marti,Peter R. Preiser,Richárd Bártfai,Till S. Voss,Till S. Voss +23 more
TL;DR: A comprehensive analysis of heterochromatin landscapes across different Plasmodium species, strains, and life cycle stages reveals conserved and specialized features of epigenetic control across the genus Plas modium.