E
Elena A. Goun
Researcher at University of Central Florida
Publications - 22
Citations - 1413
Elena A. Goun is an academic researcher from University of Central Florida. The author has contributed to research in topics: Luciferase & Decarbonylation. The author has an hindex of 12, co-authored 20 publications receiving 1292 citations. Previous affiliations of Elena A. Goun include University of California, San Francisco & École Polytechnique Fédérale de Lausanne.
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Journal ArticleDOI
The design of guanidinium-rich transporters and their internalization mechanisms.
TL;DR: An overview of recent work pertinent to the design and mechanism of uptake of guanidinium-rich transporters is provided to enable delivery of polar and non-polar drugs or probes as well as to enhance uptake of those of intermediate polarity.
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In Vivo Molecular Bioluminescence Imaging: New Tools and Applications
TL;DR: In vivo bioluminescence imaging is an optical molecular imaging technique used to visualize molecular and cellular processes in health and diseases and to follow the fate of cells with high sensitivity using luciferase-based gene reporters.
Journal ArticleDOI
Releasable luciferin-transporter conjugates: tools for the real-time analysis of cellular uptake and release
Lisa R. Jones,Elena A. Goun,Rajesh R. Shinde,Jonathan B. Rothbard,Christopher H. Contag,Paul A. Wender +5 more
TL;DR: The design, synthesis, and evaluation of conjugates of arginine-rich transporters andLuciferin are described that release luciferin only after entry into cells that are stably transfected with luciferase, providing a method to assay uptake and release of free luciferIn as a function of variations in the releasable linker and in the transporter.
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Molecular transporters: synthesis of oligoguanidinium transporters and their application to drug delivery and real-time imaging.
TL;DR: Research in this area offers the possibility of improving the bioavailability of existing drugs, enabling the delivery of new cargoes and drug candidates, and accessing difficult sites for cell penetration, all of which could dramatically enhance human therapy and the fundamental understanding of living systems.
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Antibacterial and antifungal activity of Indonesian ethnomedical plants.
TL;DR: Methylene chloride and methanol extracts of 20 Indonesian plants with ethnomedical uses have been assessed for in vitro antibacterial and antifungal properties by disk diffusion method as discussed by the authors.