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Journal ArticleDOI

In Vivo Molecular Bioluminescence Imaging: New Tools and Applications

Laura Mezzanotte, +4 more
- 01 Jul 2017 - 
- Vol. 35, Iss: 7, pp 640-652
TLDR
In vivo bioluminescence imaging is an optical molecular imaging technique used to visualize molecular and cellular processes in health and diseases and to follow the fate of cells with high sensitivity using luciferase-based gene reporters.
About: 
This article is published in Trends in Biotechnology.The article was published on 2017-07-01. It has received 204 citations till now. The article focuses on the topics: Bioluminescence imaging & Molecular imaging.

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Citations
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Journal ArticleDOI

Ratiometric optical nanoprobes enable accurate molecular detection and imaging

Xiaolin Huang, +7 more
- 23 Apr 2018 - 
TL;DR: This review elaborates upon existing optical nanoprobes that exploit ratiometric measurements for improved sensing and imaging, including fluorescence, surface enhanced Raman scattering (SERS), and photoacoustic nanoprops, and their potential biomedical applications for targeting specific biomolecule populations.
Journal ArticleDOI

Phototoxicity in live fluorescence microscopy, and how to avoid it.

Jaroslav Icha, +3 more
- 01 Aug 2017 - 
TL;DR: It is argued that phototoxicity needs increased attention from researchers when designing experiments, and when evaluating research findings, because there are often subtler consequences of illumination that are imperceptible when only the morphology of samples is examined.
Journal ArticleDOI

Single Cell Electrochemiluminescence Imaging: From the Proof-of-Concept to Disposable Device-Based Analysis

Giovanni Valenti, +10 more
- 08 Nov 2017 - 
TL;DR: The development of coreactant-based electrogenerated chemiluminescence (ECL) as a surface-confined microscopy to image single cells and their membrane proteins should find promising applications in ultrasensitive single cell imaging assays.
Journal ArticleDOI

Recent Progress in Small-Molecule Near-IR Probes for Bioimaging.

Jun-Bin Li, +7 more
TL;DR: This review focuses on the most recent advances in the development of small-molecule NIR probes and their applications in bioimaging, and highlights the challenges and opportunities in this rapidly developing field.
Journal ArticleDOI

Development and Applications of Bioluminescent and Chemiluminescent Reporters and Biosensors

Hsien-Wei Yeh, +1 more
- 12 Jun 2019 - 
TL;DR: This review first introduces the development of bioluminescent reporters, and next, their applications in sensing biological changes in vitro and in vivo as biosensors, and discusses chemiluminescence sensors that produce photons in the absence of luciferases.
References
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Journal ArticleDOI

Extracellular vesicles: biology and emerging therapeutic opportunities

Samir El Andaloussi, +4 more
- 01 May 2013 - 
TL;DR: Recent progress in understanding extracellular vesicle biology and the role of extrace cellular vesicles in disease is reviewed, emerging therapeutic opportunities are discussed and the associated challenges are considered.
Journal ArticleDOI

Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate.

Mary P. Hall, +18 more
- 30 Aug 2012 - 
TL;DR: A novel bioluminescence system capable of more efficient light emission with superior biochemical and physical characteristics is engineered in mammalian cells by merging optimization of protein structure with development of a novel imidazopyrazinone substrate (furimazine).
Journal ArticleDOI

Advances in In Vivo Bioluminescence Imaging of Gene Expression

Christopher H. Contag, +1 more
- 01 Jan 2002 - 
TL;DR: In vivo bioluminescence imaging has been combined with in vivo fluorescence imaging methods, which has enabled the real-time study of immune cell trafficking, of various genetic regulatory elements in transgenic mice, and of in vivo gene transfer.
Journal ArticleDOI

Photonic detection of bacterial pathogens in living hosts

Christopher H. Contag, +6 more
- 01 Nov 1995 - 
TL;DR: This paper developed a method for detecting bacterial pathogens in a living host and used this method to evaluate disease processes for strains of Salmonella typhimurium that differ in their virulence for mice.
Journal ArticleDOI

Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter.

Charles P. Lai, +7 more
- 09 Jan 2014 - 
TL;DR: The EVs are dynamically processed in vivo with accurate spatiotemporal resolution and target a number of normal organs as well as tumors with implications for disease pathology and therapeutic design.
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A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging

Takahiro Kuchimaru, +7 more
- 14 Jun 2016 - 

Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate.

Mary P. Hall, +18 more
- 30 Aug 2012 - 

1001 lights: luciferins, luciferases, their mechanisms of action and applications in chemical analysis, biology and medicine

Zinaida M. Kaskova, +5 more
- 24 Oct 2016 - 

A bright cyan-excitable orange fluorescent protein facilitates dual-emission microscopy and enhances bioluminescence imaging in vivo

Jun Chu, +21 more
- 01 Jul 2016 -