E
Elena Hartmann
Researcher at University of Würzburg
Publications - 72
Citations - 6747
Elena Hartmann is an academic researcher from University of Würzburg. The author has contributed to research in topics: Mantle cell lymphoma & Gene expression profiling. The author has an hindex of 32, co-authored 70 publications receiving 6079 citations.
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Journal ArticleDOI
Stromal gene signatures in large-B-cell lymphomas
Georg Lenz,George E. Wright,Sandeep S. Dave,Wenming Xiao,Jonathan D. Powell,Hong Zhao,Weihong Xu,Bruce K. Tan,Neta Goldschmidt,Javeed Iqbal,Julie M. Vose,Martin Bast,Kai Fu,Dennis D. Weisenburger,Timothy C. Greiner,James O. Armitage,Alastair H. Kyle,Lorraine May,Randy D. Gascoyne,Joseph M. Connors,Gunhild Trøen,Harald Holte,Stein Kvaløy,Daan Dierickx,Gregor Verhoef,Jan Delabie,Erlend B. Smeland,Pedro Jares,A. Martinez,Armando López-Guillermo,Emili Montserrat,Elias Campo,Rita M. Braziel,Thomas P. Miller,Lisa M. Rimsza,James R. Cook,Brad Pohlman,John Sweetenham,Raymond R. Tubbs,Richard I. Fisher,Elena Hartmann,Andreas Rosenwald,German Ott,German Ott,H-K Muller-Hermelink,D Wrench,T. A. Lister,Elaine S. Jaffe,Wyndham H. Wilson,Wing C. Chan,Louis M. Staudt +50 more
TL;DR: Survival after treatment of diffuse large-B-cell lymphoma is influenced by differences in immune cells, fibrosis, and angiogenesis in the tumor microenvironment, and a multivariate model created from three gene-expression signatures predicted survival both in patients who received CHOP and patients who receive R-CHOP.
Journal ArticleDOI
Landscape of somatic mutations and clonal evolution in mantle cell lymphoma
Sílvia Beà,Rafael Valdés-Mas,Alba Navarro,Itziar Salaverria,David Martín-García,Pedro Jares,Eva Giné,Magda Pinyol,Cristina Royo,Ferran Nadeu,Laura Conde,Manel Juan,Guillem Clot,Pedro Vizán,Luciano Di Croce,Diana A. Puente,Mónica López-Guerra,Alexandra Moros,Gaël Roué,Marta Aymerich,Neus Villamor,Lluis Colomo,Antonio Martinez,Alexandra Valera,José I. Martín-Subero,Virginia Amador,Luis Hernández,María Rozman,Anna Enjuanes,Pilar Forcada,Ana Muntañola,Elena Hartmann,María José Calasanz,Andreas Rosenwald,German Ott,Jesús M. Hernández-Rivas,Wolfram Klapper,Reiner Siebert,Adrian Wiestner,Wyndham H. Wilson,Dolors Colomer,Armando López-Guillermo,Carlos López-Otín,Xose S. Puente,Elias Campo +44 more
TL;DR: This study identifies molecular mechanisms contributing to MCL pathogenesis and offers potential targets for therapeutic intervention.
Journal ArticleDOI
Genomic and Gene Expression Profiling Defines Indolent Forms of Mantle Cell Lymphoma
Verònica Fernàndez,Olga Salamero,Blanca Espinet,Francesc Solé,Cristina Royo,Alba Navarro,Francisca I. Camacho,Sílvia Beà,Elena Hartmann,Virginia Amador,Luis Hernández,Claudio Agostinelli,Rachel L. Sargent,María Rozman,Marta Aymerich,Dolors Colomer,Neus Villamor,Steven H. Swerdlow,Stefano Pileri,Francesc Bosch,Miguel A. Piris,Emili Montserrat,German Ott,Andreas Rosenwald,Armando López-Guillermo,Pedro Jares,Sergi Serrano,Elias Campo +27 more
TL;DR: Nonnodal presentation, predominantly hypermutated IGVH, lack of genomic complexity, and absence of SOX11 expression are defined as qualities of a specific subtype of iMCL with excellent outcomes that might be managed more conservatively than cMCL.
Journal ArticleDOI
SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype
Ana Mozos,Cristina Royo,Elena Hartmann,Daphne de Jong,Cristina Baró,Alexandra Valera,Kai Fu,Dennis D. Weisenburger,Jan Delabie,Shih Sung Chuang,Elaine S. Jaffe,Carmen Ruiz-Marcellan,Sandeep S. Dave,Lisa M. Rimsza,Rita M. Braziel,Randy D. Gascoyne,Francisco Solè,Armando López-Guillermo,Dolors Colomer,Louis M. Staudt,Andreas Rosenwald,German Ott,Pedro Jares,Elias Campo +23 more
TL;DR: The clinico-pathological features and outcomes of the patients with cyclin D1-negative mantle cell lymphoma identified by SOX11 expression were similar to those of patients with conventional mantlecell lymphoma.
Journal ArticleDOI
High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation
Jan A. Burger,Maite P. Quiroga,Elena Hartmann,Andrea Bürkle,William G. Wierda,Michael J. Keating,Andreas Rosenwald +6 more
TL;DR: A novel mechanism of cross talk between CLL cells and their microenvironment is revealed, namely, the secretion of 2 T-cell chemokines in response to NLC coculture and BCR stimulation.