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Gaël Roué

Researcher at Hebron University

Publications -  122
Citations -  9138

Gaël Roué is an academic researcher from Hebron University. The author has contributed to research in topics: Mantle cell lymphoma & Apoptosis. The author has an hindex of 32, co-authored 106 publications receiving 8261 citations. Previous affiliations of Gaël Roué include Autonomous University of Barcelona & University of Caen Lower Normandy.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status

TL;DR: Noxa RNA interference markedly decreased sensitivity to bortezomib, pointing to this protein as a key mediator between proteasome inhibition and mitochondrial depolarization in MCL cells, suggesting that up-regulation of Noxa might counteract Mcl-1 accumulation after bortzomib treatment.
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The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

TL;DR: GX15-070 alone or in combination with bortezomib represents a new attractive therapeutic approach for MCL treatment and shows no significant cytotoxic effect in peripheral blood mononuclear cells from healthy donors.
Journal ArticleDOI

SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma

TL;DR: The results suggest that SOX11 contributes to tumor development by altering the terminal B-cell differentiation program of MCL and provide perspectives that may have clinical implications in the diagnosis and design of new therapeutic strategies.