C
Cristina Royo
Researcher at University of Barcelona
Publications - 32
Citations - 4116
Cristina Royo is an academic researcher from University of Barcelona. The author has contributed to research in topics: Mantle cell lymphoma & IGHV@. The author has an hindex of 25, co-authored 32 publications receiving 3601 citations.
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Journal ArticleDOI
Non-coding recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Sílvia Beà,Rafael Valdés-Mas,Neus Villamor,Jesús Gutiérrez-Abril,José I. Martín-Subero,Marta Munar,Carlota Rubio-Perez,Pedro Jares,Marta Aymerich,Tycho Baumann,Renée Beekman,Laura Belver,Anna Carrió,Giancarlo Castellano,Guillem Clot,Enrique Colado,Dolors Colomer,Dolors Costa,Julio Delgado,Anna Enjuanes,Xavier Estivill,Adolfo A. Ferrando,Josep Lluís Gelpí,Blanca Gonzalez,Santiago Gonzalez,Marcos González,Marta Gut,Jesús M. Hernández-Rivas,Mónica López-Guerra,David Martín-García,Alba Navarro,Pilar Nicolás,Modesto Orozco,Angel Ramirez Payer,Magda Pinyol,David G. Pisano,Diana A. Puente,Ana C. Queirós,Víctor Quesada,Carlos M. Romeo-Casabona,Cristina Royo,Romina Royo,María Rozman,Nuria Russiñol,Itziar Salaverria,Kostas Stamatopoulos,Hendrik G. Stunnenberg,David Tamborero,María José Terol,Alfonso Valencia,Nuria Lopez-Bigas,David Torrents,Ivo Gut,Armando López-Guillermo,Carlos López-Otín,Elias Campo +56 more
TL;DR: An integrated portrait of the CLL genomic landscape is provided, new recurrent driver mutations of the disease are identified, and clinical interventions that may improve the management of this neoplasia are suggested.
Journal ArticleDOI
Landscape of somatic mutations and clonal evolution in mantle cell lymphoma
Sílvia Beà,Rafael Valdés-Mas,Alba Navarro,Itziar Salaverria,David Martín-García,Pedro Jares,Eva Giné,Magda Pinyol,Cristina Royo,Ferran Nadeu,Laura Conde,Manel Juan,Guillem Clot,Pedro Vizán,Luciano Di Croce,Diana A. Puente,Mónica López-Guerra,Alexandra Moros,Gaël Roué,Marta Aymerich,Neus Villamor,Lluis Colomo,Antonio Martinez,Alexandra Valera,José I. Martín-Subero,Virginia Amador,Luis Hernández,María Rozman,Anna Enjuanes,Pilar Forcada,Ana Muntañola,Elena Hartmann,María José Calasanz,Andreas Rosenwald,German Ott,Jesús M. Hernández-Rivas,Wolfram Klapper,Reiner Siebert,Adrian Wiestner,Wyndham H. Wilson,Dolors Colomer,Armando López-Guillermo,Carlos López-Otín,Xose S. Puente,Elias Campo +44 more
TL;DR: This study identifies molecular mechanisms contributing to MCL pathogenesis and offers potential targets for therapeutic intervention.
Journal ArticleDOI
Genomic and Gene Expression Profiling Defines Indolent Forms of Mantle Cell Lymphoma
Verònica Fernàndez,Olga Salamero,Blanca Espinet,Francesc Solé,Cristina Royo,Alba Navarro,Francisca I. Camacho,Sílvia Beà,Elena Hartmann,Virginia Amador,Luis Hernández,Claudio Agostinelli,Rachel L. Sargent,María Rozman,Marta Aymerich,Dolors Colomer,Neus Villamor,Steven H. Swerdlow,Stefano Pileri,Francesc Bosch,Miguel A. Piris,Emili Montserrat,German Ott,Andreas Rosenwald,Armando López-Guillermo,Pedro Jares,Sergi Serrano,Elias Campo +27 more
TL;DR: Nonnodal presentation, predominantly hypermutated IGVH, lack of genomic complexity, and absence of SOX11 expression are defined as qualities of a specific subtype of iMCL with excellent outcomes that might be managed more conservatively than cMCL.
Journal ArticleDOI
SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype
Ana Mozos,Cristina Royo,Elena Hartmann,Daphne de Jong,Cristina Baró,Alexandra Valera,Kai Fu,Dennis D. Weisenburger,Jan Delabie,Shih Sung Chuang,Elaine S. Jaffe,Carmen Ruiz-Marcellan,Sandeep S. Dave,Lisa M. Rimsza,Rita M. Braziel,Randy D. Gascoyne,Francisco Solè,Armando López-Guillermo,Dolors Colomer,Louis M. Staudt,Andreas Rosenwald,German Ott,Pedro Jares,Elias Campo +23 more
TL;DR: The clinico-pathological features and outcomes of the patients with cyclin D1-negative mantle cell lymphoma identified by SOX11 expression were similar to those of patients with conventional mantlecell lymphoma.
Journal ArticleDOI
Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1 and ATM mutations in chronic lymphocytic leukemia
Ferran Nadeu,Julio Delgado,Cristina Royo,Tycho Baumann,Tatjana Stankovic,Magda Pinyol,Pedro Jares,Alba Navarro,David Martín-García,Sílvia Beà,Itziar Salaverria,Ceri E. Oldreive,Marta Aymerich,Helena Suárez-Cisneros,María Rozman,Neus Villamor,Dolors Colomer,Armando López-Guillermo,Marcos González,Miguel Alcoceba,María José Terol,Enrique Colado,Xose S. Puente,Carlos López-Otín,Anna Enjuanes,Elias Campo +25 more
TL;DR: Clonal evolution in longitudinal samples mainly occurred in cases with mutations in the initial samples and was observed not only after chemotherapy but also in untreated patients, suggesting that the characterization of the subclonal architecture and its dynamics in the evolution of the disease may be relevant for the management of CLL patients.