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Elena Pera
Researcher at University of Queensland
Publications - 5
Citations - 199
Elena Pera is an academic researcher from University of Queensland. The author has contributed to research in topics: Voltage clamp & Channel blocker. The author has an hindex of 5, co-authored 5 publications receiving 168 citations. Previous affiliations of Elena Pera include University of Sydney.
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Journal ArticleDOI
Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q
Tin T. Yow,Elena Pera,Nathan L. Absalom,Marika Heblinski,Graham A.R. Johnston,Jane R. Hanrahan,Mary Chebib +6 more
TL;DR: Flavonoids have been shown to have significant health benefits and are a diverse source of compounds for identifying agents with novel mechanisms of action.
Journal ArticleDOI
Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells
Amelia A. Peters,S. Y. N. Jamaludin,Kunsala T. D. S. Yapa,Silke B. Chalmers,Adrian P. Wiegmans,H. Lim,Michael J. G. Milevskiy,Iman Azimi,Felicity M. Davis,Korinne Northwood,Elena Pera,Daneth L. Marcial,Eloise Dray,Nigel J. Waterhouse,Peter J. Cabot,Thomas J. Gonda,Paraic A. Kenny,Melissa A. Brown,Kum Kum Khanna,Sarah J. Roberts-Thomson,Gregory R. Monteith +20 more
TL;DR: In this article, the authors defined the overexpression of transient receptor potential vanilloid 4 (TRPV4) in a subgroup of breast cancers of the basal molecular subtype.
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(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction.
Yue Pan,Madina R. Gerasimov,Trine Kvist,Petrine Wellendorph,Karsten K. Madsen,Elena Pera,Hyunbeom Lee,Arne Schousboe,Mary Chebib,Hans Bräuner-Osborne,Cheryl M. Craft,Jonathan D. Brodie,Wynne K. Schiffer,Stephen L. Dewey,Steven Robert Miller,Richard B. Silverman +15 more
TL;DR: 1 can be administered at significantly lower doses than vigabatrin, which suggests a potential new treatment for addiction with a significantly reduced risk of visual field defects.
Journal ArticleDOI
The voltage gated Ca2+-channel Cav3.2 and therapeutic responses in breast cancer
Elena Pera,Elke Kaemmerer,Elke Kaemmerer,Michael J. G. Milevskiy,Kunsala T. D. S. Yapa,Jake S. O’Donnell,Jake S. O’Donnell,Melissa A. Brown,Fiona Simpson,Fiona Simpson,Amelia A. Peters,Sarah J. Roberts-Thomson,Gregory R. Monteith,Gregory R. Monteith +13 more
TL;DR: Elevated levels of Cav3.2 may be a potential differential biomarker for survival and treatment response in specific breast cancer subtypes and add to the complex and diverse role of Ca2+-signalling in breast cancer progression and treatment.
Journal ArticleDOI
Presence of multiple binding sites on α9α10 nAChR receptors alludes to stoichiometric-dependent action of the α-conotoxin, Vc1.1.
Dinesh C. Indurthi,Elena Pera,Hye Lim Kim,Cindy Chu,Malcolm D. McLeod,J. Michael McIntosh,J. Michael McIntosh,Nathan L. Absalom,Mary Chebib +8 more
TL;DR: Using 2-electrode voltage clamp methods and maintaining a constant intracellular Ca(2+) concentration, this study observed a biphasic activation curve for ACh that is dependent on receptor stoichiometry and infer that there is an additional binding site for A Ch and Vc1.1 at the α9-α9 interface on the hypothesized (α9)₃(α10)⁂ nAChR.