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Elena Tchougounova
Researcher at Swedish University of Agricultural Sciences
Publications - 6
Citations - 1073
Elena Tchougounova is an academic researcher from Swedish University of Agricultural Sciences. The author has contributed to research in topics: Mast cell & Chymase. The author has an hindex of 6, co-authored 6 publications receiving 1013 citations.
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Journal ArticleDOI
Mice lacking histidine decarboxylase exhibit abnormal mast cells
Hiroshi Ohtsu,Satoshi Tanaka,Tadashi Terui,Yoshio Hori,Yoko Makabe-Kobayashi,Gunnar Pejler,Elena Tchougounova,Lars Hellman,Marina Gertsenstein,Noriyasu Hirasawa,Eiko Sakurai,Edit I. Buzás,Péter Kovács,György Csaba,Ágnes Kittel,Mikiko Okada,Masahiro Hara,Lynn Mar,Keiko Numayama-Tsuruta,Satsuki Ishigaki-Suzuki,Kazuo Ohuchi,Atsushi Ichikawa,András Falus,Takehiko Watanabe,Andras Nagy,Andras Nagy +25 more
TL;DR: These HDC‐deficient mice are viable and fertile but exhibit a decrease in the numbers of mast cells while the remaining mast cells show an altered morphology and reduced granular content.
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A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2.
Elena Tchougounova,Anders Lundequist,Ignacio Fajardo,Jan-Olof Winberg,Magnus Åbrink,Gunnar Pejler +5 more
TL;DR: A key role for mast cell chymase is indicated in the regulation of pro-MMP-2 and -9 activities and the results suggest an important role in regulating connective tissue homeostasis.
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The Chymase, Mouse Mast Cell Protease 4, Constitutes the Major Chymotrypsin-like Activity in Peritoneum and Ear Tissue. A Role for Mouse Mast Cell Protease 4 in Thrombin Regulation and Fibronectin Turnover
TL;DR: A role for mMCP-4 in connective tissue remodeling was suggested by the inability of mM CP-4 null peritoneal cells to process endogenous fibronectin, and a role in regulating the extravascular coagulation system was suggested.
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Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II.
TL;DR: Results of this study indicate that mast cell chymase and CPA have key roles in both the generation and degradation of Ang II.
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Altered Processing of Fibronectin in Mice Lacking Heparin A ROLE FOR HEPARIN-DEPENDENT MAST CELL CHYMASE IN FIBRONECTIN DEGRADATION
TL;DR: A biological function for chymase/heparin proteoglycan complexes in fibronectin turnover is indicated, which indicates the possible functional consequences of the lack of sulfated heparin in NDST-2−/− mice.