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Elena Tomasello
Researcher at Aix-Marseille University
Publications - 61
Citations - 9184
Elena Tomasello is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Interleukin 21 & Lymphokine-activated killer cell. The author has an hindex of 36, co-authored 57 publications receiving 8258 citations. Previous affiliations of Elena Tomasello include French Institute of Health and Medical Research & Washington University in St. Louis.
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Journal ArticleDOI
Functions of natural killer cells
Eric Vivier,Elena Tomasello,Elena Tomasello,Myriam Baratin,Myriam Baratin,Thierry Walzer,Thierry Walzer,Sophie Ugolini,Sophie Ugolini +8 more
TL;DR: Although NK cells might appear to be redundant in several conditions of immune challenge in humans, NK cell manipulation seems to hold promise in efforts to improve hematopoietic and solid organ transplantation, promote antitumor immunotherapy and control inflammatory and autoimmune disorders.
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Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin.
Carmelo Luci,Ana Reynders,Ivaylo I. Ivanov,Céline Cognet,Laurent Chiche,Lionel Chasson,Jean Hardwigsen,Esperanza Anguiano,Jacques Banchereau,Damien Chaussabel,Marc Dalod,Dan R. Littman,Eric Vivier,Elena Tomasello +13 more
TL;DR: The data show that lymphoid tissue–inducer cells and natural killer cells shared unanticipated similarities and emphasize the heterogeneity of NKp46+CD3− cells in innate immunity, lymphoid organization and local tissue repair.
Journal ArticleDOI
The trafficking of natural killer cells
Claude Grégoire,Lionel Chasson,Lionel Chasson,Carmelo Luci,Carmelo Luci,Elena Tomasello,Elena Tomasello,Frederic Geissmann,Eric Vivier,Thierry Walzer,Thierry Walzer +10 more
TL;DR: The tissue localization of NK cells is described, using NKp46 as an NK cell marker, and the current knowledge on the mechanisms that govern their trafficking in humans and in mice is reviewed.
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Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D
Andreas Diefenbach,Elena Tomasello,Mathias Lucas,Amanda M. Jamieson,Jennifer K. Hsia,Eric Vivier,David H. Raulet +6 more
TL;DR: It is reported that alternative splicing leads to two distinct NKG2D polypeptides that associate differentially with the DAP10 and KARAP signaling subunits, which suggests a rationale for the multisubunit structure of stimulatory immunoreceptors.
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A novel dendritic cell subset involved in tumor immunosurveillance.
Julien Taieb,Nathalie Chaput,Cédric Ménard,Lionel Apetoh,Evelyn Ullrich,Mathieu Bonmort,Marie O. Pequignot,Noelia Casares,Magali Terme,Caroline Flament,Paule Opolon,Yann Lécluse,Didier Métivier,Elena Tomasello,Eric Vivier,François Ghiringhelli,François Martin,David Klatzmann,Thierry Poynard,Thomas Tursz,Graça Raposo,Hideo Yagita,Bernard Ryffel,Guido Kroemer,Laurence Zitvogel +24 more
TL;DR: Adoptive transfer of these IFN-producing killer dendritic cells into tumor-bearing Rag2/−Il2rg−/− mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not and was identified as pivotal sensors and effectors of the innate antitumor immune response.