B
Bernard Ryffel
Researcher at University of Orléans
Publications - 43
Citations - 6266
Bernard Ryffel is an academic researcher from University of Orléans. The author has contributed to research in topics: Immune system & Tumor necrosis factor alpha. The author has an hindex of 30, co-authored 43 publications receiving 5704 citations. Previous affiliations of Bernard Ryffel include University of Cape Town & Centre national de la recherche scientifique.
Papers
More filters
Journal ArticleDOI
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.
Lionel Apetoh,François Ghiringhelli,Antoine Tesniere,Antoine Tesniere,Antoine Tesniere,Michel Obeid,Michel Obeid,Michel Obeid,Carla Ortiz,Carla Ortiz,Carla Ortiz,Alfredo Criollo,Alfredo Criollo,Alfredo Criollo,Grégoire Mignot,Grégoire Mignot,Grégoire Mignot,M. Chiara Maiuri,Evelyn Ullrich,Evelyn Ullrich,Evelyn Ullrich,Patrick Saulnier,Huan Yang,Sebastian Amigorena,Bernard Ryffel,Franck J. Barrat,Paul Saftig,Francis Lévi,Francis Lévi,Rosette Lidereau,Catherine Noguès,Jean-Paul Mira,Agnès Chompret,Virginie Joulin,Françoise Clavel-Chapelon,Jean Bourhis,Fabrice Andre,Suzette Delaloge,T. Tursz,Guido Kroemer,Guido Kroemer,Guido Kroemer,Laurence Zitvogel +42 more
TL;DR: A previously unrecognized pathway for the activation of tumor antigen–specific T-cell immunity that involves secretion of the high-mobility-group box 1 (HMGB1) alarmin protein by dying tumor cells and the action of HMGB1 on Toll-like receptor 4 (TLR4) expressed by dendritic cells (DCs) is described.
Journal ArticleDOI
A novel dendritic cell subset involved in tumor immunosurveillance.
Julien Taieb,Nathalie Chaput,Cédric Ménard,Lionel Apetoh,Evelyn Ullrich,Mathieu Bonmort,Marie O. Pequignot,Noelia Casares,Magali Terme,Caroline Flament,Paule Opolon,Yann Lécluse,Didier Métivier,Elena Tomasello,Eric Vivier,François Ghiringhelli,François Martin,David Klatzmann,Thierry Poynard,Thomas Tursz,Graça Raposo,Hideo Yagita,Bernard Ryffel,Guido Kroemer,Laurence Zitvogel +24 more
TL;DR: Adoptive transfer of these IFN-producing killer dendritic cells into tumor-bearing Rag2/−Il2rg−/− mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not and was identified as pivotal sensors and effectors of the innate antitumor immune response.
Journal ArticleDOI
Detection of prokaryotic mRNA signifies microbial viability and promotes immunity
Leif E. Sander,Michael J. Davis,Mark V. Boekschoten,Derk Amsen,Christopher C. Dascher,Bernard Ryffel,Joel A. Swanson,Michael Müller,J. Magarian Blander +8 more
TL;DR: It is shown that the mammalian innate immune system can directly sense microbial viability through detection of a special class of viability-associated PAMPs (vita-PAMPs), which could combine the superior protection of live vaccines with the safety of dead vaccines.
Journal ArticleDOI
Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy.
Yuting Ma,Laetitia Aymeric,Clara Locher,Stephen R. Mattarollo,Nicolas F. Delahaye,Pablo Pereira,Laurent Boucontet,Lionel Apetoh,François Ghiringhelli,Noelia Casares,Juan José Lasarte,Goro Matsuzaki,Koichi Ikuta,Bernard Ryffel,Kamel Benlagha,Antoine Tesniere,Nicolas Ibrahim,Julie Déchanet-Merville,Nathalie Chaput,Mark J. Smyth,Guido Kroemer,Laurence Zitvogel +21 more
TL;DR: IL-17 production by γδ T cells is required for tumor cell infiltration by IFN-γ–producing CD8+ T cells and inhibition of tumor growth in response to anthracyclines.
Journal ArticleDOI
Erratum: Detection of prokaryotic mRNA signifies microbial viability and promotes immunity
Leif E. Sander,Michael Davis,Mark V. Boekschoten,Derk Amsen,Christopher C. Dascher,Bernard Ryffel,Joel A. Swanson,Michael Müller,J. Magarian Blander +8 more
TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is based on a two-step process, not a single step, like in the previous version of this paper.