E
Elina Ikonen
Researcher at Minerva Foundation Institute for Medical Research
Publications - 207
Citations - 26902
Elina Ikonen is an academic researcher from Minerva Foundation Institute for Medical Research. The author has contributed to research in topics: Endosome & Lipid droplet. The author has an hindex of 60, co-authored 197 publications receiving 24542 citations. Previous affiliations of Elina Ikonen include University of Helsinki & University of Geneva.
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Journal ArticleDOI
ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol.
Annika Koponen,Amita Arora,Kohta Takahashi,Henriikka Kentala,Annukka M. Kivelä,Eeva Jääskeläinen,Johan Peränen,Pentti Somerharju,Elina Ikonen,Tapani Viitala,Vesa M. Olkkonen,Vesa M. Olkkonen +11 more
TL;DR: The data demonstrates that ORP2 binds several phosphoinositides, both PI(4)P and multiply phosphorylated species, and regulates the subcellular distribution of cholesterol dependent on its PIP-binding capacity.
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Human leucocyte aspartylglucosaminidase. Evidence for two different subunits in a more complex native structure.
TL;DR: Human leucocyte aspartylglucosaminidase (AGA) was purified to homogeneity by using affinity chromatography, gel filtration, chromatofocusing and reverse-phase h.p.l.c., and immunological data obtained with antisera produced against these subunits showed that AGA consists of two non-identical polypeptides.
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Concerted regulation of npc2 binding to endosomal/lysosomal membranes by bis(monoacylglycero)phosphate and sphingomyelin.
Giray Enkavi,Giray Enkavi,Heikki Mikkolainen,Burcin Gungor,Burcin Gungor,Elina Ikonen,Elina Ikonen,Ilpo Vattulainen,Ilpo Vattulainen +8 more
TL;DR: The results provide concrete evidence that lipids modulate npc2-mediated cholesterol transport either by favoring or disfavoring Prone mode and that they impose this by modulating the accessibility of bmp for interacting with nPC2.
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Tracking Sphingosine Metabolism and Transport in Sphingolipidoses: NPC1 Deficiency as a Test Case
TL;DR: Evidence against NPC1 playing a significant role in LE/LY sphingosine export was obtained in experiments using the [3H]‐sphingolipids or a fluorescent sphinga derivative in NPC1 knock‐out cells, and instead, NPC1‐deficient cells displayed an increased affinity for sphingoine independently of protein‐mediated lipid transport.
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Molecular mechanisms of intracellular cholesterol transport
TL;DR: Two previously cloned proteins were discovered to play a role in sterol transport of steroidogenic cells: the scavenger receptor BI as an HDL receptor and steroidogenic acute regulatory protein in the transport of cholesterol to mitochondria.