E
Elina Ikonen
Researcher at Minerva Foundation Institute for Medical Research
Publications - 207
Citations - 26902
Elina Ikonen is an academic researcher from Minerva Foundation Institute for Medical Research. The author has contributed to research in topics: Endosome & Lipid droplet. The author has an hindex of 60, co-authored 197 publications receiving 24542 citations. Previous affiliations of Elina Ikonen include University of Helsinki & University of Geneva.
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Seipin traps triacylglycerols to facilitate their nanoscale clustering in the ER membrane
Xavier Prasanna,Veijo T. Salo,Veijo T. Salo,Shiqian Li,Shiqian Li,Katharina Ven,Katharina Ven,Helena Vihinen,Eija Jokitalo,Ilpo Vattulainen,Elina Ikonen,Elina Ikonen +11 more
TL;DR: It is suggested that seipin traps TAGs via its luminal hydrophobic helices, serving as a catalyst for seeding the TAG cluster from dissolved monomers inside the seipIn ring, thereby generating a favorable promethin binding interface.
Posted ContentDOI
ATPase activity of DFCP1 controls selective autophagy
Viola Nähse,Camilla Raiborg,Kia Wee Tan,Sissel Mørk,Maria Lyngaas Torgersen,Eva Maria Wenzel,Mireia Nàger,Veijo T. Salo,Terje Johansen,Elina Ikonen,Kay Oliver Schink,Harald Stenmark +11 more
TL;DR: It is demonstrated that DFCP1 is an ATPase that dimerizes in an ATP-dependent fashion and mediates ATPase-driven constriction of omegasomes to release autophagosomes for selective autophagy.
Posted ContentDOI
Association of tamoxifen resistance and lipid reprogramming in breast cancer
Susanne Hultsch,Matti Kankainen,Lassi Paavolainen,Ruusu-Maaria Kovanen,Elina Ikonen,Sara Kangaspeska,Vilja Pietiaeinen,Olli Kallioniemi +7 more
TL;DR: It is shown that tamoxifen resistance cannot simply be explained by altered expression of individual genes, common mechanism across all resistant variants, or the appearance of new fusion genes, and novel drug vulnerabilities associated with this phenotype are suggested.
Cln5-deficiency in mice leads to microglial activation, defective myelination and changes in lipid metabolism
Mia-Lisa Schmiedt,Tea Blom,Tomas Blom,Outi Kopra,Andrew Wong,Carina von Schantz-Fant,Elina Ikonen,Mervi Kuronen,Matti Jauhiainen,Jonathan D. Cooper,Anu Jalanko,Anu Jalanko +11 more
TL;DR: This article studied the gene expression of Cln5 in the mouse brain and showed that it increases gradually with age and differs between neurons and glia, with the highest expression in microglia.